Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Facile Synthesis of Weakly Ferromagnetic Organogadolinium Macrochelates‐Based T1‐Weighted Magnetic Resonance Imaging Contrast Agents
To surmount the major concerns of commercial small molecule Gd chelates and reported Gd‐based contrast agents (GBCAs) for magnetic resonance imaging (MRI), a new concept of organogadolinium macrochelates (OGMCs) constructed from the coordination between Gd3+ and macromolecules is proposed. A library of macromolecules were screened for Gd3+ coordination, and two candidates [i.e., poly(acrylic acid) (PAA), and poly(aspartic acid) (PASP)] succeeded in OGMC formation. Under optimized synthesis conditions, both Gd‐PAA12 and Gd‐PASP11 OGMCs are outstanding T1‐weighted CAs owing to their super high r1 values (> 50 mm−1 s−1, 3.0 T) and ultralow r2/r1 ratios (< 1.6, 3.0 T). The ferromagnetism of OGMCs is completely different from the paramagnetism of commercial and reported GBCAs. The ferromagnetism is very weak (Ms < 1.0 emu g−1) leading to a low r2, which is preferred for T1 MRI. Gd3+ is not released from the OGMC Gd‐PAA12 and Gd‐PASP11, ensuring biosafety for in vivo applications. The safety and T1‐weighted MRI efficiencies of the OGMC Gd‐PAA12 and Gd‐PASP11 are tested in cells and mice. The synthesis method of the OGMCs is facile and easy to be scaled up. Consequently, the OGMC Gd‐PAA12 and Gd‐PASP11 are superior T1‐weighted CAs with promising translatability to replace the commercial Gd chelates.
Facile Synthesis of Weakly Ferromagnetic Organogadolinium Macrochelates‐Based T1‐Weighted Magnetic Resonance Imaging Contrast Agents
To surmount the major concerns of commercial small molecule Gd chelates and reported Gd‐based contrast agents (GBCAs) for magnetic resonance imaging (MRI), a new concept of organogadolinium macrochelates (OGMCs) constructed from the coordination between Gd3+ and macromolecules is proposed. A library of macromolecules were screened for Gd3+ coordination, and two candidates [i.e., poly(acrylic acid) (PAA), and poly(aspartic acid) (PASP)] succeeded in OGMC formation. Under optimized synthesis conditions, both Gd‐PAA12 and Gd‐PASP11 OGMCs are outstanding T1‐weighted CAs owing to their super high r1 values (> 50 mm−1 s−1, 3.0 T) and ultralow r2/r1 ratios (< 1.6, 3.0 T). The ferromagnetism of OGMCs is completely different from the paramagnetism of commercial and reported GBCAs. The ferromagnetism is very weak (Ms < 1.0 emu g−1) leading to a low r2, which is preferred for T1 MRI. Gd3+ is not released from the OGMC Gd‐PAA12 and Gd‐PASP11, ensuring biosafety for in vivo applications. The safety and T1‐weighted MRI efficiencies of the OGMC Gd‐PAA12 and Gd‐PASP11 are tested in cells and mice. The synthesis method of the OGMCs is facile and easy to be scaled up. Consequently, the OGMC Gd‐PAA12 and Gd‐PASP11 are superior T1‐weighted CAs with promising translatability to replace the commercial Gd chelates.
Facile Synthesis of Weakly Ferromagnetic Organogadolinium Macrochelates‐Based T1‐Weighted Magnetic Resonance Imaging Contrast Agents
Lu, Yudie (Autor:in) / Liang, Zhiyu (Autor:in) / Feng, Jie (Autor:in) / Huang, Lin (Autor:in) / Guo, Shuai (Autor:in) / Yi, Peiwei (Autor:in) / Xiong, Wei (Autor:in) / Chen, Sijin (Autor:in) / Yang, Sugeun (Autor:in) / Xu, Yikai (Autor:in)
Advanced Science ; 10
01.01.2023
11 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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