Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
A LDH‐Derived Metal Sulfide Nanosheet‐Functionalized Bioactive Glass Scaffold for Vascularized Osteogenesis and Periprosthetic Infection Prevention/Treatment
Periprosthetic infection and prosthetic loosing stand out as prevalent yet formidable complications following orthopedic implant surgeries. Synchronously addressing the two complications is long‐time challenging. Herein, a bioactive glass scaffold (BGS) functionalized with MgCuFe‐layered double hydroxide (LDH)‐derived sulfide nanosheets (BGS/MCFS) is developed for vascularized osteogenesis and periprosthetic infection prevention/treatment. Apart from the antibacterial cations inhibiting bacterial energy and material metabolism, the exceptional near‐infrared‐II (NIR‐II) photothermal performance empowers BGS/MCFS to eliminate periprosthetic infections, outperforming previously reported functionalized BGS. The rough surface topography and the presence of multi‐bioactive metal ions bestow BGS/MCFS with exceptional osteogenic and angiogenic properties, with 8.5‐fold and 2.3‐fold enhancement in bone mass and neovascularization compared with BGS. Transcriptome sequencing highlights the involvement of the TGF‐β signaling pathway in these processes, while single‐cell sequencing reveals a significant increase in osteoblasts and endothelial cells around BGS/MCFS compared to BGS.
A LDH‐Derived Metal Sulfide Nanosheet‐Functionalized Bioactive Glass Scaffold for Vascularized Osteogenesis and Periprosthetic Infection Prevention/Treatment
Periprosthetic infection and prosthetic loosing stand out as prevalent yet formidable complications following orthopedic implant surgeries. Synchronously addressing the two complications is long‐time challenging. Herein, a bioactive glass scaffold (BGS) functionalized with MgCuFe‐layered double hydroxide (LDH)‐derived sulfide nanosheets (BGS/MCFS) is developed for vascularized osteogenesis and periprosthetic infection prevention/treatment. Apart from the antibacterial cations inhibiting bacterial energy and material metabolism, the exceptional near‐infrared‐II (NIR‐II) photothermal performance empowers BGS/MCFS to eliminate periprosthetic infections, outperforming previously reported functionalized BGS. The rough surface topography and the presence of multi‐bioactive metal ions bestow BGS/MCFS with exceptional osteogenic and angiogenic properties, with 8.5‐fold and 2.3‐fold enhancement in bone mass and neovascularization compared with BGS. Transcriptome sequencing highlights the involvement of the TGF‐β signaling pathway in these processes, while single‐cell sequencing reveals a significant increase in osteoblasts and endothelial cells around BGS/MCFS compared to BGS.
A LDH‐Derived Metal Sulfide Nanosheet‐Functionalized Bioactive Glass Scaffold for Vascularized Osteogenesis and Periprosthetic Infection Prevention/Treatment
Bian, Yixin (Autor:in) / Hu, Tingting (Autor:in) / Zhao, Kexin (Autor:in) / Cai, Xuejie (Autor:in) / Li, Mengyang (Autor:in) / Tan, Chaoliang (Autor:in) / Liang, Ruizheng (Autor:in) / Weng, Xisheng (Autor:in)
Advanced Science ; 11
01.10.2024
13 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Engineered porous scaffolds for periprosthetic infection prevention
| British Library Online Contents | 2016
Engineered porous scaffolds for periprosthetic infection prevention
| British Library Online Contents | 2016
Engineered porous scaffolds for periprosthetic infection prevention
| British Library Online Contents | 2016
Phage Nanofibers Induce Vascularized Osteogenesis in 3D Printed Bone Scaffolds
| British Library Online Contents | 2014