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Arsenic exposure induces genomic hypermethylation

Majumdar, Sunipa / Chanda, Sarmishtha / Ganguli, Bhaswati / Mazumder, D. N. Guha / Lahiri, Sarbari / Dasgupta, Uma B.

Gene‐specific hypermethylation has previously been detected in Arsenic exposed persons. To monitor the level of whole genome methylation in persons exposed to different levels of Arsenic via drinking water, DNA was extracted from peripheral blood mononuclear cells of 64 persons. Uptake of methyl group from ³H labeled S‐Adenosyl Methionine after incubation of DNA with SssI methylase was measured. Results showed statistically significant (P = 0.0004) decrease in uptake of ³H methyl group in the persons exposed to 250–500 μg/L arsenic, indicating genomic hypermethylation. © 2009 Wiley Periodicals, Inc. Environ Toxicol, 2010.

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Arsenic exposure induces genomic hypermethylation

Majumdar, Sunipa / Chanda, Sarmishtha / Ganguli, Bhaswati / Mazumder, D. N. Guha / Lahiri, Sarbari / Dasgupta, Uma B.

Gene‐specific hypermethylation has previously been detected in Arsenic exposed persons. To monitor the level of whole genome methylation in persons exposed to different levels of Arsenic via drinking water, DNA was extracted from peripheral blood mononuclear cells of 64 persons. Uptake of methyl group from ³H labeled S‐Adenosyl Methionine after incubation of DNA with SssI methylase was measured. Results showed statistically significant (P = 0.0004) decrease in uptake of ³H methyl group in the persons exposed to 250–500 μg/L arsenic, indicating genomic hypermethylation. © 2009 Wiley Periodicals, Inc. Environ Toxicol, 2010.

Arsenic exposure induces genomic hypermethylation

Majumdar, Sunipa / Chanda, Sarmishtha / Ganguli, Bhaswati / Mazumder, D. N. Guha / Lahiri, Sarbari / Dasgupta, Uma B.

Gene‐specific hypermethylation has previously been detected in Arsenic exposed persons. To monitor the level of whole genome methylation in persons exposed to different levels of Arsenic via drinking water, DNA was extracted from peripheral blood mononuclear cells of 64 persons. Uptake of methyl group from ³H labeled S‐Adenosyl Methionine after incubation of DNA with SssI methylase was measured. Results showed statistically significant (P = 0.0004) decrease in uptake of ³H methyl group in the persons exposed to 250–500 μg/L arsenic, indicating genomic hypermethylation. © 2009 Wiley Periodicals, Inc. Environ Toxicol, 2010.

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Titel:

Arsenic exposure induces genomic hypermethylation

Beteiligte:

Majumdar, Sunipa (Autor:in) / Chanda, Sarmishtha (Autor:in) / Ganguli, Bhaswati (Autor:in) / Mazumder, D. N. Guha (Autor:in) / Lahiri, Sarbari (Autor:in) / Dasgupta, Uma B. (Autor:in)

Erschienen in:

Environmental Toxicology ; 25 ; 315-318

Erscheinungsdatum:

01.06.2010

Format / Umfang:

4 pages

ISSN:

1522-7278 , 1520-4081

DOI:

https://doi.org/10.1002/tox.20497

Medientyp:

Aufsatz (Zeitschrift)

Format:

Elektronische Ressource

Sprache:

Englisch

Schlagwörter:

hypomethylation , India , genomic hypermethylation , arsenic

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