Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents
10.1002/tox.20418.abs
The effects of nano particles of CuO on voltage‐dependent potassium currents were studied in acutely isolated CA1 pyramidal neurons of rat hippocampus using the whole‐cell patch‐clamp techniques. Nano particles of CuO had small effects on transient outward potassium current (IA, no statistical significance) and mainly inhibited delayed rectifier potassium current (IK) in the concentration of 5 × 10−5 g/mL. Nano particles of CuO didn't shift the steady‐state activation curve of IK and IA but negatively shifted the inactivation curve of IK. The effects on inactivation curve of IA had no statistical significance. These results suggested that blockades of K+ currents by nano particles of CuO could be preferential for Ik for the first time. This may interfere with the normal function of nerve cells. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2009.
In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents
10.1002/tox.20418.abs
The effects of nano particles of CuO on voltage‐dependent potassium currents were studied in acutely isolated CA1 pyramidal neurons of rat hippocampus using the whole‐cell patch‐clamp techniques. Nano particles of CuO had small effects on transient outward potassium current (IA, no statistical significance) and mainly inhibited delayed rectifier potassium current (IK) in the concentration of 5 × 10−5 g/mL. Nano particles of CuO didn't shift the steady‐state activation curve of IK and IA but negatively shifted the inactivation curve of IK. The effects on inactivation curve of IA had no statistical significance. These results suggested that blockades of K+ currents by nano particles of CuO could be preferential for Ik for the first time. This may interfere with the normal function of nerve cells. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2009.
In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents
Xu, Lan‐Ju (Autor:in) / Zhao, Jing‐Xia (Autor:in) / Zhang, Tao (Autor:in) / Ren, Guo‐Gang (Autor:in) / Yang, Zhuo (Autor:in)
Environmental Toxicology ; 24 ; 211-217
01.06.2009
7 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Potassium Currents in Developing Neurons
| British Library Conference Proceedings | 1999
The inhibitory effects of nano‐Ag on voltage‐gated potassium currents of hippocampal CA1 neurons
| Online Contents | 2011
ToF-SIMS cluster ion imaging of hippocampal CA1 pyramidal rat neurons
| British Library Online Contents | 2008