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A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia
Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood. Here the authors show that sevoflurane activates a cluster of urocortin 1 (UCN1+)/cocaine‐ and amphetamine‐regulated transcript (CART+) neurons in the midbrain involved in its anesthesia. Furthermore, growth hormone secretagogue receptor (GHSR) is highly enriched in sevoflurane‐activated UCN1+/CART+ cells and is necessary for sleep induction. Blockade of GHSR abolishes the excitatory effect of sevoflurane on UCN1+/CART+ neurons and attenuates its anesthetic effect. Collectively, their data suggest that anesthetic action of sevoflurane necessitates the GHSR activation in midbrain UCN1+/CART+ neurons, which provides a novel target including the nucleus and receptor in the field of anesthesia.
A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia
Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood. Here the authors show that sevoflurane activates a cluster of urocortin 1 (UCN1+)/cocaine‐ and amphetamine‐regulated transcript (CART+) neurons in the midbrain involved in its anesthesia. Furthermore, growth hormone secretagogue receptor (GHSR) is highly enriched in sevoflurane‐activated UCN1+/CART+ cells and is necessary for sleep induction. Blockade of GHSR abolishes the excitatory effect of sevoflurane on UCN1+/CART+ neurons and attenuates its anesthetic effect. Collectively, their data suggest that anesthetic action of sevoflurane necessitates the GHSR activation in midbrain UCN1+/CART+ neurons, which provides a novel target including the nucleus and receptor in the field of anesthesia.
A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia
Yi, Tingting (Autor:in) / Wang, Na (Autor:in) / Huang, Jing (Autor:in) / Wang, Yaling (Autor:in) / Ren, Shuancheng (Autor:in) / Hu, Yiwen (Autor:in) / Xia, Jianxia (Autor:in) / Liao, Yixiang (Autor:in) / Li, Xin (Autor:in) / Luo, Fenlan (Autor:in)
Advanced Science ; 10
01.05.2023
16 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch