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Green Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma
Retinoblastoma is one of the most severe ocular diseases, of which current chemotherapy is limited to the repetitive intravitreal injections of chemotherapeutics. Systemic drug administration is a less invasive route; however, it is also less efficient for ocular drug delivery because of the existence of blood‐retinal barrier and systemic side effects. Here, a photoresponsive drug release system is reported, which is self‐assembled from photocleavable trigonal small molecules, to achieve light‐triggered intraocular drug accumulation. After intravenous injection of drug‐loaded nanocarriers, green light can trigger the disassembly of the nanocarriers in retinal blood vessels, which leads to intraocular drug release and accumulation to suppress retinoblastoma growth. This proof‐of‐concept study would advance the development of light‐triggered drug release systems for the intravenous treatment of eye diseases.
Green Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma
Retinoblastoma is one of the most severe ocular diseases, of which current chemotherapy is limited to the repetitive intravitreal injections of chemotherapeutics. Systemic drug administration is a less invasive route; however, it is also less efficient for ocular drug delivery because of the existence of blood‐retinal barrier and systemic side effects. Here, a photoresponsive drug release system is reported, which is self‐assembled from photocleavable trigonal small molecules, to achieve light‐triggered intraocular drug accumulation. After intravenous injection of drug‐loaded nanocarriers, green light can trigger the disassembly of the nanocarriers in retinal blood vessels, which leads to intraocular drug release and accumulation to suppress retinoblastoma growth. This proof‐of‐concept study would advance the development of light‐triggered drug release systems for the intravenous treatment of eye diseases.
Green Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma
Long, Kaiqi (Autor:in) / Yang, Yang (Autor:in) / Lv, Wen (Autor:in) / Jiang, Kuan (Autor:in) / Li, Yafei (Autor:in) / Lo, Amy Cheuk Yin (Autor:in) / Lam, Wai Ching (Autor:in) / Zhan, Changyou (Autor:in) / Wang, Weiping (Autor:in)
Advanced Science ; 8
01.10.2021
10 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
| Wiley | 2021
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