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Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo
Early‐stage stroke monitoring enables timely intervention that is crucial to minimizing neuronal damage and increasing the extent of recovery. By monitoring collateral circulation and neovascularization after ischemic stroke, the natural recovery process can be better understood, optimize further treatment strategies, and improve the prognosis. Photoacoustic computed tomography (PACT), a non‐invasive imaging modality that captures multiparametric high‐resolution images of vessel structures, is well suited for evaluating cerebrovascular structures and their function. Here 3D multiparametric transcranial PACT is implemented to monitor the early stage of a photothrombotic (PT)‐stroke model in living rats. New vessels in the PT‐induced region are successfully observed using PACT, and these observations are confirmed by histology. Then, using multiparametric PACT, it is found that the SO2 in the ischemic area decreases while the SO2 in newly formed vessels increases, and the SO2 in the PT region also recovers. These findings demonstrate PACT's remarkable ability to image and monitor cerebrovascular morphologic and physiological changes. They highlight the usefulness of whole‐brain PACT as a potentially powerful tool for early diagnosis and therapeutic decision‐making in treating ischemic stroke.
Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo
Early‐stage stroke monitoring enables timely intervention that is crucial to minimizing neuronal damage and increasing the extent of recovery. By monitoring collateral circulation and neovascularization after ischemic stroke, the natural recovery process can be better understood, optimize further treatment strategies, and improve the prognosis. Photoacoustic computed tomography (PACT), a non‐invasive imaging modality that captures multiparametric high‐resolution images of vessel structures, is well suited for evaluating cerebrovascular structures and their function. Here 3D multiparametric transcranial PACT is implemented to monitor the early stage of a photothrombotic (PT)‐stroke model in living rats. New vessels in the PT‐induced region are successfully observed using PACT, and these observations are confirmed by histology. Then, using multiparametric PACT, it is found that the SO2 in the ischemic area decreases while the SO2 in newly formed vessels increases, and the SO2 in the PT region also recovers. These findings demonstrate PACT's remarkable ability to image and monitor cerebrovascular morphologic and physiological changes. They highlight the usefulness of whole‐brain PACT as a potentially powerful tool for early diagnosis and therapeutic decision‐making in treating ischemic stroke.
Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo
Kim, Jiwoong (Autor:in) / Kweon, Joo Young (Autor:in) / Choi, Seongwook (Autor:in) / Jeon, Hyunseo (Autor:in) / Sung, Minsik (Autor:in) / Gao, Rongkang (Autor:in) / Liu, Chengbo (Autor:in) / Kim, Chulhong (Autor:in) / Ahn, Yong Joo (Autor:in)
Advanced Science ; 12
01.01.2025
10 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo
| Wiley | 2025
Master strokes - Meeting report
Online Contents | 2004
| British Library Online Contents | 2008