Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Toxicokinetic modeling for environmental health problems
10.1002/env.576.abs
Toxicokinetic (TK) and physiologically based toxicokinetic (PB‐TK) models enable tissue dosimetry and the definition of the target organ dose after exposure to exogenous toxic compounds. This has qualified PB‐TK models for extrapolation from the experimental animal to the human, from high to low doses, between routes of exposure, between patterns of exposure, and also between robust and susceptible sub‐populations. We show how PB‐TK models are constructed, what assumptions are needed, which mathematical methods are used for model building and by which statistical methods one may assess both model fit and uncertainty of the modeling itself. We will address in particular a new generation of PB‐TK models which include age‐dependent model parameters to model life‐long human exposure with an example from the exposure to dioxins. Finally, we define the role of PB‐TK models for the identification of human health effects after exposure to chemicals in risk assessment. Copyright © 2003 John Wiley & Sons, Ltd.
Toxicokinetic modeling for environmental health problems
10.1002/env.576.abs
Toxicokinetic (TK) and physiologically based toxicokinetic (PB‐TK) models enable tissue dosimetry and the definition of the target organ dose after exposure to exogenous toxic compounds. This has qualified PB‐TK models for extrapolation from the experimental animal to the human, from high to low doses, between routes of exposure, between patterns of exposure, and also between robust and susceptible sub‐populations. We show how PB‐TK models are constructed, what assumptions are needed, which mathematical methods are used for model building and by which statistical methods one may assess both model fit and uncertainty of the modeling itself. We will address in particular a new generation of PB‐TK models which include age‐dependent model parameters to model life‐long human exposure with an example from the exposure to dioxins. Finally, we define the role of PB‐TK models for the identification of human health effects after exposure to chemicals in risk assessment. Copyright © 2003 John Wiley & Sons, Ltd.
Toxicokinetic modeling for environmental health problems
Edler, Lutz (Autor:in) / Heinzl, Harald (Autor:in)
Environmetrics ; 14 ; 193-202
01.03.2003
10 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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