Glutathione‐Responsive Nanoparticles of Camptothecin Prodrug for Cancer Therapy: Fid-Bau Portal

Fachinformationsdienst BAUdigital

Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik

Glutathione‐Responsive Nanoparticles of Camptothecin Prodrug for Cancer Therapy

Zhang, Lingpu / Zhu, Lin / Tang, Lin / Xie, Jiayi / Gao, Yajuan / Yu, Changyuan / Shang, Kun / Han, Hongbin / Liu, Chaoyong / Lu, Yunfeng

Camptothecin (CPT) is a potent chemotherapeutic agent for various cancers, but the broader application of CPT is still hindered by its poor bioavailability and systemic toxicity. Here, a prodrug that releases CPT in response to glutathione (GSH), which is commonly overexpressed by cancer cells is reported. Through assembling with PEGylated lipids, the prodrug is incorporated within as‐assembled nanoparticles, affording CPT with a prolonged half‐life in blood circulation, enhanced tumor targetingability, and improved therapeutic efficacy. Furthermore, such prodrug nanoparticles can also promote dendritic cell maturation and tumor infiltration of CD8⁺ T cells, providing a novel strategy to improve the therapeutic efficacy of CPT.

Zugriff

Seitennavigation

Dokumentinformationen

Ähnliche Titel

Exportieren, teilen und zitieren

Glutathione‐Responsive Nanoparticles of Camptothecin Prodrug for Cancer Therapy

Zhang, Lingpu / Zhu, Lin / Tang, Lin / Xie, Jiayi / Gao, Yajuan / Yu, Changyuan / Shang, Kun / Han, Hongbin / Liu, Chaoyong / Lu, Yunfeng

Camptothecin (CPT) is a potent chemotherapeutic agent for various cancers, but the broader application of CPT is still hindered by its poor bioavailability and systemic toxicity. Here, a prodrug that releases CPT in response to glutathione (GSH), which is commonly overexpressed by cancer cells is reported. Through assembling with PEGylated lipids, the prodrug is incorporated within as‐assembled nanoparticles, affording CPT with a prolonged half‐life in blood circulation, enhanced tumor targetingability, and improved therapeutic efficacy. Furthermore, such prodrug nanoparticles can also promote dendritic cell maturation and tumor infiltration of CD8⁺ T cells, providing a novel strategy to improve the therapeutic efficacy of CPT.

Glutathione‐Responsive Nanoparticles of Camptothecin Prodrug for Cancer Therapy

Zhang, Lingpu / Zhu, Lin / Tang, Lin / Xie, Jiayi / Gao, Yajuan / Yu, Changyuan / Shang, Kun / Han, Hongbin / Liu, Chaoyong / Lu, Yunfeng

Camptothecin (CPT) is a potent chemotherapeutic agent for various cancers, but the broader application of CPT is still hindered by its poor bioavailability and systemic toxicity. Here, a prodrug that releases CPT in response to glutathione (GSH), which is commonly overexpressed by cancer cells is reported. Through assembling with PEGylated lipids, the prodrug is incorporated within as‐assembled nanoparticles, affording CPT with a prolonged half‐life in blood circulation, enhanced tumor targetingability, and improved therapeutic efficacy. Furthermore, such prodrug nanoparticles can also promote dendritic cell maturation and tumor infiltration of CD8⁺ T cells, providing a novel strategy to improve the therapeutic efficacy of CPT.

Zugriff

Seitennavigation

Dokumentinformationen

Ähnliche Titel

Exportieren, teilen und zitieren

Dokumentinformationen

Titel:

Glutathione‐Responsive Nanoparticles of Camptothecin Prodrug for Cancer Therapy

Beteiligte:

Zhang, Lingpu (Autor:in) / Zhu, Lin (Autor:in) / Tang, Lin (Autor:in) / Xie, Jiayi (Autor:in) / Gao, Yajuan (Autor:in) / Yu, Changyuan (Autor:in) / Shang, Kun (Autor:in) / Han, Hongbin (Autor:in) / Liu, Chaoyong (Autor:in) / Lu, Yunfeng (Autor:in)

Erschienen in:

Advanced Science ; 10

Erscheinungsdatum:

01.01.2023

Format / Umfang:

10 pages

ISSN:

DOI:

https://doi.org/10.1002/advs.202205246

Medientyp:

Aufsatz (Zeitschrift)

Format:

Elektronische Ressource

Sprache:

Englisch

Schlagwörter:

cancer immunotherapy , controlled release , CPT prodrug , glutathione responsive , self‐assembly

Ähnliche Titel

Polymeric Nanoparticles with ROS‐Responsive Prodrug and Platinum Nanozyme for Enhanced Chemophotodynamic Therapy of Colon Cancer

Hao, Ying / Chen, Yuwen / He, Xinlong et al. | Wiley | 2020

Freier Zugriff

Microenvironment‐Responsive Prodrug‐Induced Pyroptosis Boosts Cancer Immunotherapy

Xiao, Yao / Zhang, Tian / Ma, Xianbin et al. | Wiley | 2021

Freier Zugriff

Tumor Redox Heterogeneity-Responsive Prodrug Nanocapsules for Cancer Chemotherapy

Wang, J. / Sun, X. / Mao, W. et al. | British Library Online Contents | 2013

Nanoparticulation of Prodrug into Medicines for Cancer Therapy

Zhang, Yuezhou / Cui, Huaguang / Zhang, Ruiqi et al. | Wiley | 2021

Freier Zugriff

Hypoxia‐Responsive Prodrug of ATR Inhibitor, AZD6738, Selectively Eradicates Treatment‐Resistant Cancer Cells

Barnieh, Francis M. / Morais, Goreti Ribeiro / Loadman, Paul M. et al. | Wiley | 2024

Freier Zugriff