Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Multipotent Poly(Tertiary Amine‐Oxide) Micelles for Efficient Cancer Drug Delivery
The cancer drug delivery process involves a series of biological barriers, which require the nanomedicine to exhibit different, even opposite properties for high therapeutic efficacy. The prevailing design philosophy, i.e., integrating these properties within one nanomedicine via on‐demand property transitions such as PEGylation/dePEGylation, complicates nanomedicines’ composition and thus impedes clinical translation. Here, polyzwitterionic micelles of poly(tertiary amine‐oxide)‐block‐poly(ε‐caprolactone) (PTAO‐PCL) amphiphiles that enable all the required functions are presented. The zwitterionic nature and unique cell membrane affinity confer the PTAO micelles long blood circulation, efficient tumor accumulation and penetration, and fast cellular internalization. The mitochondrial targeting capability allows drug delivery into the mitochondria to induce mitochondrial dysfunction and overcome tumor multidrug resistance. As a result, the PTAO/drug micelles exhibit potent anticancer efficacy. This simple yet multipotent carrier system holds great promise as a generic platform for potential clinical translation.
Multipotent Poly(Tertiary Amine‐Oxide) Micelles for Efficient Cancer Drug Delivery
The cancer drug delivery process involves a series of biological barriers, which require the nanomedicine to exhibit different, even opposite properties for high therapeutic efficacy. The prevailing design philosophy, i.e., integrating these properties within one nanomedicine via on‐demand property transitions such as PEGylation/dePEGylation, complicates nanomedicines’ composition and thus impedes clinical translation. Here, polyzwitterionic micelles of poly(tertiary amine‐oxide)‐block‐poly(ε‐caprolactone) (PTAO‐PCL) amphiphiles that enable all the required functions are presented. The zwitterionic nature and unique cell membrane affinity confer the PTAO micelles long blood circulation, efficient tumor accumulation and penetration, and fast cellular internalization. The mitochondrial targeting capability allows drug delivery into the mitochondria to induce mitochondrial dysfunction and overcome tumor multidrug resistance. As a result, the PTAO/drug micelles exhibit potent anticancer efficacy. This simple yet multipotent carrier system holds great promise as a generic platform for potential clinical translation.
Multipotent Poly(Tertiary Amine‐Oxide) Micelles for Efficient Cancer Drug Delivery
Xiang, Jiajia (Autor:in) / Shen, Yihuai (Autor:in) / Zhang, Yifan (Autor:in) / Liu, Xin (Autor:in) / Zhou, Quan (Autor:in) / Zhou, Zhuxian (Autor:in) / Tang, Jianbin (Autor:in) / Shao, Shiqun (Autor:in) / Shen, Youqing (Autor:in)
Advanced Science ; 9
01.04.2022
13 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
| British Library Online Contents | 2018
| British Library Online Contents | 2018
Synthesis of Poly(ether ether ketone)s containing tertiary amine
| British Library Online Contents | 2007
Dual-targeted biodegradable micelles for anticancer drug delivery
| British Library Online Contents | 2019
| British Library Online Contents | 2015