Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Propamocarb exposure decreases the secretion of neurotransmitters and causes behavioral impairments in mice
Propamocarb (PM) is a type of fungicide, which is widely used in the greenhouse‐based production of vegetables and fruits globally. It has been considered to have generally low toxicity. However, the teratogenicity or neurotoxicity for mammals remains unclear. In this study, we aimed to explore its effect on the secretion of neurotransmitters and behavioral impairments. Male adult mice were exposed to 10 and 40 mg/L PM for 2 weeks (acute exposure) or 3 and 10 mg/L PM for 10 weeks (chronic exposure). It was observed that acute or chronic exposure to PM changed the levels of serotonin (5‐HT) and dopamine in the serum and colon and the transcription of TPH2 and DRD2 in the colons of mice. In addition, the locomotor test, the open field test, and the Morris water maze analysis also showed that acute exposure to PM caused behavioral impairments to some extent. The results obtained in the present study indicated that PM has the potential to induce neurotoxicity in animals.
Propamocarb exposure decreases the secretion of neurotransmitters and causes behavioral impairments in mice
Propamocarb (PM) is a type of fungicide, which is widely used in the greenhouse‐based production of vegetables and fruits globally. It has been considered to have generally low toxicity. However, the teratogenicity or neurotoxicity for mammals remains unclear. In this study, we aimed to explore its effect on the secretion of neurotransmitters and behavioral impairments. Male adult mice were exposed to 10 and 40 mg/L PM for 2 weeks (acute exposure) or 3 and 10 mg/L PM for 10 weeks (chronic exposure). It was observed that acute or chronic exposure to PM changed the levels of serotonin (5‐HT) and dopamine in the serum and colon and the transcription of TPH2 and DRD2 in the colons of mice. In addition, the locomotor test, the open field test, and the Morris water maze analysis also showed that acute exposure to PM caused behavioral impairments to some extent. The results obtained in the present study indicated that PM has the potential to induce neurotoxicity in animals.
Propamocarb exposure decreases the secretion of neurotransmitters and causes behavioral impairments in mice
Zhang, Yi (Autor:in) / Jin, Cuiyuan (Autor:in) / Wang, Xiaoyu (Autor:in) / Shen, Manlu (Autor:in) / Zhou, Jiajie (Autor:in) / Wu, Sisheng (Autor:in) / Fu, Zhengwei (Autor:in) / Jin, Yuanxiang (Autor:in)
Environmental Toxicology ; 34 ; 22-29
01.01.2019
8 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Impairments in Fire Protection and Their Causes
| Wiley | 1933
Long-term arsenic exposure decreases mice body weight and liver lipid droplets
| DOAJ | 2024
Exposure to bifenthrin causes immunotoxicity and oxidative stress in male mice
| Online Contents | 2014
Repeated exposure to iron oxide nanoparticles causes testicular toxicity in mice
| Online Contents | 2017