Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Anti‐apoptosis Function of PBCA Nanoparticles Containing Caspase‐3 siRNA for Neuronal Protection
Poly(butylcyanoacrylate) nanoparticles (PBCA NPs) have the ability to cross the blood‐brain barrier and deliver pharmaceuticals into the brain. Caspase‐3 (Casp3)‐siRNA loaded NPs were designed to investigate the possibility of anti‐apoptotic treatment. NPs were produced in a miniemulsion and optimized according to size and zeta potential. Casp3‐PBCA NP induced anti‐apoptotic effect was observed by an MTT test and siRNA caused knock‐down effect was identified by using a western blot assay. Further, rhodamine‐123 labeled PBCA NPs were visualized by in vivo imaging to investigate the blood‐brain barrier passage in a rodent experiment.
Anti‐apoptosis Function of PBCA Nanoparticles Containing Caspase‐3 siRNA for Neuronal Protection
Poly(butylcyanoacrylate) nanoparticles (PBCA NPs) have the ability to cross the blood‐brain barrier and deliver pharmaceuticals into the brain. Caspase‐3 (Casp3)‐siRNA loaded NPs were designed to investigate the possibility of anti‐apoptotic treatment. NPs were produced in a miniemulsion and optimized according to size and zeta potential. Casp3‐PBCA NP induced anti‐apoptotic effect was observed by an MTT test and siRNA caused knock‐down effect was identified by using a western blot assay. Further, rhodamine‐123 labeled PBCA NPs were visualized by in vivo imaging to investigate the blood‐brain barrier passage in a rodent experiment.
Anti‐apoptosis Function of PBCA Nanoparticles Containing Caspase‐3 siRNA for Neuronal Protection
Zhang, Xiwei (Autor:in) / Zhang, Enqi (Autor:in) / Grigartzik, Lisa (Autor:in) / Henrich‐Noack, Petra (Autor:in) / Hintz, Werner (Autor:in) / Sabel, Bernhard A. (Autor:in)
Chemie Ingenieur Technik ; 90 ; 451-455
01.04.2018
5 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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