A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Evaluation of Cyclophosphamide on the Behavior and Reproduction of Daphnia magna
https://orcid.org/0000-0002-1413-6051
https://orcid.org/0000-0002-3988-3483
https://orcid.org/0000-0002-6962-3957
Anticancer drugs in waters may increase potential threats on the future persistence of aquatic organism with their actions on cell death in targeted cell types of neoplasia, such as cyclophosphamide (CP). The potential adverse effects of CP may be exacerbated by the enhanced detection frequency and levels in different waters. Thus, the mechanisms of CP on the Daphnia magna are elucidated in this study. Our results found aspartic acid, citric acid, tyrosine, isoleucine, phenylalanine, phenyl-acetaldehyde, phenyl-acetylglutamine, trans-cinnamate, and methionine as core metabolites identified in response to CP by LC-MS-based metabolic analysis, implying the disruption of amino acid, energy, and lipid metabolism pathways. Differentially expressed genes by transcriptomic analysis were mainly associated with the nervous system and lipid metabolism. For the behavior and reproduction performances, CP not only increased the light response and swimming velocity of D. magna but also delayed the time to first brood, decreased the number of broods, and increased the number of neonates per brood. Overall, our findings suggest that CP alters the behavior and reproduction, the metabolites, and transcriptional expression associated with the nervous system and metabolism pathways and provides some evidence on the mechanisms of CP toxicity in D. magna and perhaps other zooplankton.
This work is on the effects of cyclophosphamide in zooplankton and sheds new light on water management of emerging contaminants.
Evaluation of Cyclophosphamide on the Behavior and Reproduction of Daphnia magna
https://orcid.org/0000-0002-1413-6051
https://orcid.org/0000-0002-3988-3483
https://orcid.org/0000-0002-6962-3957
Anticancer drugs in waters may increase potential threats on the future persistence of aquatic organism with their actions on cell death in targeted cell types of neoplasia, such as cyclophosphamide (CP). The potential adverse effects of CP may be exacerbated by the enhanced detection frequency and levels in different waters. Thus, the mechanisms of CP on the Daphnia magna are elucidated in this study. Our results found aspartic acid, citric acid, tyrosine, isoleucine, phenylalanine, phenyl-acetaldehyde, phenyl-acetylglutamine, trans-cinnamate, and methionine as core metabolites identified in response to CP by LC-MS-based metabolic analysis, implying the disruption of amino acid, energy, and lipid metabolism pathways. Differentially expressed genes by transcriptomic analysis were mainly associated with the nervous system and lipid metabolism. For the behavior and reproduction performances, CP not only increased the light response and swimming velocity of D. magna but also delayed the time to first brood, decreased the number of broods, and increased the number of neonates per brood. Overall, our findings suggest that CP alters the behavior and reproduction, the metabolites, and transcriptional expression associated with the nervous system and metabolism pathways and provides some evidence on the mechanisms of CP toxicity in D. magna and perhaps other zooplankton.
This work is on the effects of cyclophosphamide in zooplankton and sheds new light on water management of emerging contaminants.
Evaluation of Cyclophosphamide on the Behavior and Reproduction of Daphnia magna
https://orcid.org/0000-0002-1413-6051
https://orcid.org/0000-0002-3988-3483
https://orcid.org/0000-0002-6962-3957
Anticancer drugs in waters may increase potential threats on the future persistence of aquatic organism with their actions on cell death in targeted cell types of neoplasia, such as cyclophosphamide (CP). The potential adverse effects of CP may be exacerbated by the enhanced detection frequency and levels in different waters. Thus, the mechanisms of CP on the Daphnia magna are elucidated in this study. Our results found aspartic acid, citric acid, tyrosine, isoleucine, phenylalanine, phenyl-acetaldehyde, phenyl-acetylglutamine, trans-cinnamate, and methionine as core metabolites identified in response to CP by LC-MS-based metabolic analysis, implying the disruption of amino acid, energy, and lipid metabolism pathways. Differentially expressed genes by transcriptomic analysis were mainly associated with the nervous system and lipid metabolism. For the behavior and reproduction performances, CP not only increased the light response and swimming velocity of D. magna but also delayed the time to first brood, decreased the number of broods, and increased the number of neonates per brood. Overall, our findings suggest that CP alters the behavior and reproduction, the metabolites, and transcriptional expression associated with the nervous system and metabolism pathways and provides some evidence on the mechanisms of CP toxicity in D. magna and perhaps other zooplankton.
This work is on the effects of cyclophosphamide in zooplankton and sheds new light on water management of emerging contaminants.
Evaluation of Cyclophosphamide on the Behavior and Reproduction of Daphnia magna
Sun, Weijun (author) / Liu, Tianming (author) / Lei, Haojun (author) / Wei, Xinrong (author) / Li, Lixia (author) / Chen, Hongxing (author) / Li, Dan (author) / Xie, Lingtian (author)
ACS ES&T Water ; 3 ; 996-1006
2023-04-14
Article (Journal)
Electronic Resource
English
Toxicity of cypermethrin to Daphnia magna HB
| Online Contents | 2004
Multigenerational cadmium acclimation and biokinetics in Daphnia magna
| Online Contents | 2006