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Stability of Colistin and Carbapenems in Water and Wastewater
https://orcid.org/0000-0002-8998-2703
https://orcid.org/0000-0003-0032-9650
https://orcid.org/0000-0002-0087-1143
https://orcid.org/0000-0001-5399-8239
This study identified the stability of two categories of last-resort antibiotics: colistin (colistins A and B) and carbapenems (meropenem, doripenem, biapenem, and ertapenem) in water and wastewater. Colistin and carbapenems at −20 °C showed a considerable degradation over 3 weeks, with the highest decay noted for ertapenem. Under an acidic pH, all carbapenems showed a comparable level of decay in both water and wastewater. However, under neutral pH, the degradation under wastewater (k ww = 0–0.0117 h–1) was higher than in water (k w = 0–0.0042 h–1). For colistin at pH 7, degradation observed in wastewater within 24 h was significantly higher than that in water, with an observed k ww of 0.44 h–1 (pH 7, 25 °C) in comparison to a k w of 0.0128 h–1. Temperature deteriorated the stability of colistin in wastewater at pH 7, as the degradation at 4 °C (40–50%) was much lower than that at 25 °C (80–90%). The stability of colistin A and B was identical in both water and wastewater under acidic conditions (pH 5) irrespective of the temperature, with an observed degradation of less than 10%. These results shed light on the environmental stability of last-resort antimicrobials for wastewater-based epidemiology and other related applications.
Stability of colistin and carbapenems as last-resort antibiotics was studied in water and wastewater for potential WBE application. Stability of colistin and carbapenems in water and wastewater with varying pH and temperature. Faster degradation observed for colistin and carbapenems at neutral and acidic pHs, respectively. Higher temperatures generally accelerated the degradation of colistin and carbapenems. Stability of colistin was not affected by temperature at an acidic pH of 5.
Stability of Colistin and Carbapenems in Water and Wastewater
https://orcid.org/0000-0002-8998-2703
https://orcid.org/0000-0003-0032-9650
https://orcid.org/0000-0002-0087-1143
https://orcid.org/0000-0001-5399-8239
This study identified the stability of two categories of last-resort antibiotics: colistin (colistins A and B) and carbapenems (meropenem, doripenem, biapenem, and ertapenem) in water and wastewater. Colistin and carbapenems at −20 °C showed a considerable degradation over 3 weeks, with the highest decay noted for ertapenem. Under an acidic pH, all carbapenems showed a comparable level of decay in both water and wastewater. However, under neutral pH, the degradation under wastewater (k ww = 0–0.0117 h–1) was higher than in water (k w = 0–0.0042 h–1). For colistin at pH 7, degradation observed in wastewater within 24 h was significantly higher than that in water, with an observed k ww of 0.44 h–1 (pH 7, 25 °C) in comparison to a k w of 0.0128 h–1. Temperature deteriorated the stability of colistin in wastewater at pH 7, as the degradation at 4 °C (40–50%) was much lower than that at 25 °C (80–90%). The stability of colistin A and B was identical in both water and wastewater under acidic conditions (pH 5) irrespective of the temperature, with an observed degradation of less than 10%. These results shed light on the environmental stability of last-resort antimicrobials for wastewater-based epidemiology and other related applications.
Stability of colistin and carbapenems as last-resort antibiotics was studied in water and wastewater for potential WBE application. Stability of colistin and carbapenems in water and wastewater with varying pH and temperature. Faster degradation observed for colistin and carbapenems at neutral and acidic pHs, respectively. Higher temperatures generally accelerated the degradation of colistin and carbapenems. Stability of colistin was not affected by temperature at an acidic pH of 5.
Stability of Colistin and Carbapenems in Water and Wastewater
https://orcid.org/0000-0002-8998-2703
https://orcid.org/0000-0003-0032-9650
https://orcid.org/0000-0002-0087-1143
https://orcid.org/0000-0001-5399-8239
This study identified the stability of two categories of last-resort antibiotics: colistin (colistins A and B) and carbapenems (meropenem, doripenem, biapenem, and ertapenem) in water and wastewater. Colistin and carbapenems at −20 °C showed a considerable degradation over 3 weeks, with the highest decay noted for ertapenem. Under an acidic pH, all carbapenems showed a comparable level of decay in both water and wastewater. However, under neutral pH, the degradation under wastewater (k ww = 0–0.0117 h–1) was higher than in water (k w = 0–0.0042 h–1). For colistin at pH 7, degradation observed in wastewater within 24 h was significantly higher than that in water, with an observed k ww of 0.44 h–1 (pH 7, 25 °C) in comparison to a k w of 0.0128 h–1. Temperature deteriorated the stability of colistin in wastewater at pH 7, as the degradation at 4 °C (40–50%) was much lower than that at 25 °C (80–90%). The stability of colistin A and B was identical in both water and wastewater under acidic conditions (pH 5) irrespective of the temperature, with an observed degradation of less than 10%. These results shed light on the environmental stability of last-resort antimicrobials for wastewater-based epidemiology and other related applications.
Stability of colistin and carbapenems as last-resort antibiotics was studied in water and wastewater for potential WBE application. Stability of colistin and carbapenems in water and wastewater with varying pH and temperature. Faster degradation observed for colistin and carbapenems at neutral and acidic pHs, respectively. Higher temperatures generally accelerated the degradation of colistin and carbapenems. Stability of colistin was not affected by temperature at an acidic pH of 5.
Stability of Colistin and Carbapenems in Water and Wastewater
Sharma, Elipsha (author) / Kelso, Celine (author) / Zhang, Shuxin (author) / Guo, Ying (author) / Sivakumar, Muttucumaru (author) / Jiang, Guangming (author)
ACS ES&T Water ; 3 ; 3496-3504
2023-11-10
Article (Journal)
Electronic Resource
English
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