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Modelling Rest-Inserted Loading in Bone Mechanotransduction Using Poroelastic Finite Element Models: The Impact of Permeability
Adaptation of bone is sensitive to mechanical loading frequency and to rest periods between consecutive load cycles. The time dependence of mechano-adaptation may be caused by a time-varying stimulus such as fluid flow. In vitro studies have shown that interstitial fluid flow (IFF) is osteogenic for bone cells. We investigated how bone permeability and rest insertion affect mechanical stimuli in the lacunar-canilicular system in simplified 3D poroelastic finite-element model of a beam in bending, representing mouse cortical bone. Load cycles with a 10 Hz haversine wave as amplitude were applied, with rest-insertion times ranging from 0-10 seconds. Intrinsic permeability values ranging from 10-23-10-18 m2 were tested. IFF was determined in the centroid of the model. We found there is an optimal rest insertion time necessary to maximize fluid motion, which depends on permeability. These findings may be utilized in developing maximally effective loading protocols.
Modelling Rest-Inserted Loading in Bone Mechanotransduction Using Poroelastic Finite Element Models: The Impact of Permeability
Adaptation of bone is sensitive to mechanical loading frequency and to rest periods between consecutive load cycles. The time dependence of mechano-adaptation may be caused by a time-varying stimulus such as fluid flow. In vitro studies have shown that interstitial fluid flow (IFF) is osteogenic for bone cells. We investigated how bone permeability and rest insertion affect mechanical stimuli in the lacunar-canilicular system in simplified 3D poroelastic finite-element model of a beam in bending, representing mouse cortical bone. Load cycles with a 10 Hz haversine wave as amplitude were applied, with rest-insertion times ranging from 0-10 seconds. Intrinsic permeability values ranging from 10-23-10-18 m2 were tested. IFF was determined in the centroid of the model. We found there is an optimal rest insertion time necessary to maximize fluid motion, which depends on permeability. These findings may be utilized in developing maximally effective loading protocols.
Modelling Rest-Inserted Loading in Bone Mechanotransduction Using Poroelastic Finite Element Models: The Impact of Permeability
Pereira, Andre F. (author) / Shefelbine, Sandra S. (author)
Fifth Biot Conference on Poromechanics ; 2013 ; Vienna, Austria
Poromechanics V ; 1137-1144
2013-06-18
Conference paper
Electronic Resource
English
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