The European building stock is ageing and requires significant renovation efforts to improve its energy performance and ensure structural safety and resilience. Within the European Green Deal, the Renovation Wave initiative promotes increases in building renovation rates to ensure that ambitious EU energy saving targets for 2030 and beyond can be achieved. To incentivise renovation further, integrating energy retrofitting with seismic strengthening is explored in the Exploratory Research project iRESIST+ by investigating a novel seismic-plus-energy retrofit. The research conducted in iRESIST+ is of high timeliness and has relevance for the policy areas related to the energy efficiency of buildings, circular-economy principles, as well as resilience. In iRESIST+, the combination of inorganic textile reinforced mortar (TRM) composites with thermal insulation materials is explored. A review of the experimental studies on TRM highlighted their potential for seismic strengthening, but also their suitability for combined seismic and energy retrofitting. Based on the gathered scientific literature, a new macro-modelling approach for TRM-strengthened infilled reinforced concrete (RC) buildings was developed, and then used to quantify the effectiveness of the retrofit in increasing the in-plane capacity of the iRESIST+ prototype structure. By conducting a series of incremental dynamic analyses, the results were expanded, showing improvements in the dynamic behaviour of mid-rise RC buildings, with reduced damage at higher earthquake intensities. Fragility curves of existing mid-rise RC buildings, typical for the EU building stock, as well as a TRM-retrofitted building were then constructed, showing that the losses of a building with low seismic design level can be reduced to those of a modern, high-code structure. A broader study on combined energy and seismic retrofitting was then conducted across twenty European cities in five different seismic and four climatic zones, in order to assess the retrofit for all possible combinations of seismic hazard and climatic conditions. Typical masonry and RC buildings were defined in terms of their energy and structural characteristics and were associated with the building population of each city. By means of building energy modelling and seismic fragility assessments, the potential reductions in losses, after applying the iRESIST+ integrated retrofitting concept, for each building type were modelled. The results were extended to the entire building stock of the case study cities to assess different renovation scenarios. In the case of non-action, i.e. keeping the current annual renovation rate of around 1%, the ambitious targets of the EU Green Deal in terms of energy use reductions cannot be achieved. Instead, if renovation rates are tripled to 3%, the energy use for heating and cooling may be reduced by up to 32.5%. This would lead to reductions of around 30% in CO2 emissions across all cities by 2030 for the residential sector. In terms of seismic performance, the assessments of different building typologies showed high seismic loss reductions particularly for older and mid-rise structures in moderate to high seismic hazard zones. A combined monetary metric based on expected annual losses was established considering energy costs and costs related to structural damage. It was found that combined retrofitting can reduce investment payback periods substantially in moderate to high seismicity regions. Overall, this report highlights the potential of combined retrofitting with TRM and thermal insulation for the EU building stock. The proposed retrofit is cost-effective and lends itself to large-scale applications due to its easy application and reduced building down-time compared to traditional retrofitting. Finally, the validity of the proposed approach will be evaluated experimentally on the iRESIST+ prototype structure at the European Commission´s Joint Research Centre (JRC) ELSA laboratory in Ispra. ; JRC.E.4 - Safety and Security of Buildings