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Management Modalities for Necrotising Enterocolitis: Targeting Toll Like Receptors
In spite of advances in the management of newborn infants, Necrotizing Enterocolitis(NEC) continues to be a complicated disease all over the world. Gradual development in the field of NEC discovered ‘Toll-like receptor 4’(TLR4), which is a bacterial receptor having role in pathogenesis of the disease. TLR4 expression is increased in bowel mucosa of NEC babies and TLR4 activation causes mucosal injury and enterocyte apoptosis. Breast feeding is considered to decrease the risk of necrotizing enterocolitis. But, we neither have a definite molecule for the treatment of the disease nor for its prevention. CpG DNA which is present in the probiotic preparations and muramyl-di-peptide(MDP), inhibit TLR4 signaling may decrease NEC severity. Epidermal growth factors(EGF) present in amniotic fluid also reduce TLR4 signaling. Heparin binding EGF( HB-EGF) and Heat shock protein(Hsp 70) are possible approaches for management of NEC because of their action on TLR4. These may be considered as future management approach for this common and compromising disease of the newborn.
Management Modalities for Necrotising Enterocolitis: Targeting Toll Like Receptors
In spite of advances in the management of newborn infants, Necrotizing Enterocolitis(NEC) continues to be a complicated disease all over the world. Gradual development in the field of NEC discovered ‘Toll-like receptor 4’(TLR4), which is a bacterial receptor having role in pathogenesis of the disease. TLR4 expression is increased in bowel mucosa of NEC babies and TLR4 activation causes mucosal injury and enterocyte apoptosis. Breast feeding is considered to decrease the risk of necrotizing enterocolitis. But, we neither have a definite molecule for the treatment of the disease nor for its prevention. CpG DNA which is present in the probiotic preparations and muramyl-di-peptide(MDP), inhibit TLR4 signaling may decrease NEC severity. Epidermal growth factors(EGF) present in amniotic fluid also reduce TLR4 signaling. Heparin binding EGF( HB-EGF) and Heat shock protein(Hsp 70) are possible approaches for management of NEC because of their action on TLR4. These may be considered as future management approach for this common and compromising disease of the newborn.
Management Modalities for Necrotising Enterocolitis: Targeting Toll Like Receptors
Tripathy, Prasanta Kumar (author) / Nanda, Rachita (author)
2016-01-02
Annals of Applied Bio-Sciences; Vol 3 No 1 (2016); R1-5 ; 2349-6991 ; 2455-0396
Article (Journal)
Electronic Resource
English
DDC:
690
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