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Investigation of agonistic and antagonistic endocrine activity during full-scale ozonation of waste water
The use of a wide variety of chemicals in our society, such as industrial chemicals, pharmaceuticals, personal care products, etc., leads to pollution of surface waters. Especially in densely populated urban areas such as the Ruhr catchment, sustainable water management poses a major challenge. Despite intensive use through various types of discharges (effluents of direct dischargers, municipal waste water treatment plants, industry, etc.), good water quality has always to be guaranteed in accordance to the European Water Framewor Directive. Endocrine disrupting chemicals can have an effect on aquatic organisms even at very low concentrations (pg/L range). In order to reduce the emission, ozonation was investigated as advanced waste water treatment for the elimination of organic trace compounds. An elimination performance of ≥ 80% for selected substances at specific ozone doses in the range of zspec. = 0.3 - 0.7 mgO3/mgDOC was achieved. Since 2015, estrogens are listed on the watch-list of the European Water Framework Directive with required detection limits in the pg/L range. These detection limits cannot be achieved with current instrumental methods. Therefore, sensitive effect based methods based on modified yeast cells (Arxula adeninivorans), which carry the human estrogen or androgen receptor, were used as a screening tool for corresponding activities. The results showed high elimination rates of the effects already at low ozone doses (zspec. = 0.3 mgO3/mgDOC). Inhibitory effects (antagonists) were investigated in parallel. No significant reduction in antagonistic effects was observed. A comprehensive analysis method based on effect-based analysis and a non-target approach using high-resolution mass spectrometry was developed to identify unknown active compounds. Due to concerns about possible toxicity of the transformation products formed during the ozonation, biological post-treatments are recommended for further treatment. To characterize the efficiency of post-treatment, the assimilable organic carbon ...
Investigation of agonistic and antagonistic endocrine activity during full-scale ozonation of waste water
The use of a wide variety of chemicals in our society, such as industrial chemicals, pharmaceuticals, personal care products, etc., leads to pollution of surface waters. Especially in densely populated urban areas such as the Ruhr catchment, sustainable water management poses a major challenge. Despite intensive use through various types of discharges (effluents of direct dischargers, municipal waste water treatment plants, industry, etc.), good water quality has always to be guaranteed in accordance to the European Water Framewor Directive. Endocrine disrupting chemicals can have an effect on aquatic organisms even at very low concentrations (pg/L range). In order to reduce the emission, ozonation was investigated as advanced waste water treatment for the elimination of organic trace compounds. An elimination performance of ≥ 80% for selected substances at specific ozone doses in the range of zspec. = 0.3 - 0.7 mgO3/mgDOC was achieved. Since 2015, estrogens are listed on the watch-list of the European Water Framework Directive with required detection limits in the pg/L range. These detection limits cannot be achieved with current instrumental methods. Therefore, sensitive effect based methods based on modified yeast cells (Arxula adeninivorans), which carry the human estrogen or androgen receptor, were used as a screening tool for corresponding activities. The results showed high elimination rates of the effects already at low ozone doses (zspec. = 0.3 mgO3/mgDOC). Inhibitory effects (antagonists) were investigated in parallel. No significant reduction in antagonistic effects was observed. A comprehensive analysis method based on effect-based analysis and a non-target approach using high-resolution mass spectrometry was developed to identify unknown active compounds. Due to concerns about possible toxicity of the transformation products formed during the ozonation, biological post-treatments are recommended for further treatment. To characterize the efficiency of post-treatment, the assimilable organic carbon ...
Investigation of agonistic and antagonistic endocrine activity during full-scale ozonation of waste water
Itzel, Fabian (author) / Schmidt, Torsten C.
2019-03-06
Theses
Electronic Resource
English
Cytokinin Agonistic and Antagonistic Properties of Sim.-Triazine and N-Pyridylcarbamate Derivatives
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Bench-Scale Ozonation of Waste Activated Sludge
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