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Early-Life Stress and Epigenetic Ageing in Preschool-Aged Children ; Lebensgeschichtlich Frühe Stresserfahrungen und Epigenetische Alterung bei Kindern im Vorschulalter
Background: Research of stress-related ageing may be crucial to tackle future burdens for health care systems. Chronic stress exposure during childhood such as exposure to maltreatment is associated with ageing-related diseases and global population as well as life expectancy is steadily increasing. However, understanding of underlying mechanisms remains cloudy. The current study investigates epigenetic ageing in children in association with various manifestations of stress exposure including psychopathology and maltreatment and biological stress. Further, epigenetic ageing is assessed in relation to stress-related biological factors including glucocorticoid signaling and inflammation. Methods: Hypotheses were tested in 158 children aged 3 to 5 years. The impact of psychopathology on epigenetic ageing was tested and maltreatment was integrated as moderator in this relationship. The association between epigenetic ageing and biological correlates of stress, i.e., Cortisol and CRP, was examined overall and in groups of differential risk for accelerated epigenetic ageing. Lastly, it was evaluated whether the pediatric buccal epigenetic (PedBE) clock is responsive to glucocorticoids. Results: Internalizing disorder significantly accelerated epigenetic ageing (F1,147 = 6.67, p = 0.011) while externalizing disorder had no effect on epigenetic ageing. Maltreatment gradually increased the effect of internalizing disorder on epigenetic ageing (b = 0.49, 95% CI [0.073, 0.909], t = 2.322, p = 0.022). Further, epigenetic ageing significantly correlated with cortisol (r [32] = 0.36, p = 0.043) and CRP (r [32] = 0.42, p = 0.016) in maltreated children with internalizing disorder. A significant amount of the PedBE clock CpG sites (18/94) was responsive to glucocorticoid exposure (OR = 4.36, p = 1.65*10–6). Conclusion: The current study identified maltreatment as catalyzer for accelerated epigenetic ageing in children with internalizing disorder and thereby expanded knowledge on stress-related ageing very early in life. This ...
Early-Life Stress and Epigenetic Ageing in Preschool-Aged Children ; Lebensgeschichtlich Frühe Stresserfahrungen und Epigenetische Alterung bei Kindern im Vorschulalter
Background: Research of stress-related ageing may be crucial to tackle future burdens for health care systems. Chronic stress exposure during childhood such as exposure to maltreatment is associated with ageing-related diseases and global population as well as life expectancy is steadily increasing. However, understanding of underlying mechanisms remains cloudy. The current study investigates epigenetic ageing in children in association with various manifestations of stress exposure including psychopathology and maltreatment and biological stress. Further, epigenetic ageing is assessed in relation to stress-related biological factors including glucocorticoid signaling and inflammation. Methods: Hypotheses were tested in 158 children aged 3 to 5 years. The impact of psychopathology on epigenetic ageing was tested and maltreatment was integrated as moderator in this relationship. The association between epigenetic ageing and biological correlates of stress, i.e., Cortisol and CRP, was examined overall and in groups of differential risk for accelerated epigenetic ageing. Lastly, it was evaluated whether the pediatric buccal epigenetic (PedBE) clock is responsive to glucocorticoids. Results: Internalizing disorder significantly accelerated epigenetic ageing (F1,147 = 6.67, p = 0.011) while externalizing disorder had no effect on epigenetic ageing. Maltreatment gradually increased the effect of internalizing disorder on epigenetic ageing (b = 0.49, 95% CI [0.073, 0.909], t = 2.322, p = 0.022). Further, epigenetic ageing significantly correlated with cortisol (r [32] = 0.36, p = 0.043) and CRP (r [32] = 0.42, p = 0.016) in maltreated children with internalizing disorder. A significant amount of the PedBE clock CpG sites (18/94) was responsive to glucocorticoid exposure (OR = 4.36, p = 1.65*10–6). Conclusion: The current study identified maltreatment as catalyzer for accelerated epigenetic ageing in children with internalizing disorder and thereby expanded knowledge on stress-related ageing very early in life. This ...
Early-Life Stress and Epigenetic Ageing in Preschool-Aged Children ; Lebensgeschichtlich Frühe Stresserfahrungen und Epigenetische Alterung bei Kindern im Vorschulalter
Dammering, Felix (author) / male / N.N.
2024-01-01
Theses
Electronic Resource
English
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