A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Necrotizing Enterocolitis Associated with Congenital Heart Disease:a Different Entity?
Background: Necrotizing enterocolitis (NEC) predominantly occurs in preterm infants (PT-NEC). In term neonates, NEC occurs more frequently when a congenital heart disease is present (CHDNEC). Our aim was to evaluate differences and similarities in disease characteristics of PT-NEC versus CHD-NEC. Methods: In this retrospective case-control study we identified all CHD infants who developed NEC Bell's stage >= 2 in our center from 2004 to 2014. We randomly selected (1:2 ratio) PT-NEC infants from the same period. Biochemical and clinical variables were retrieved from patient files. Results: We found 18 CHD-NEC infants and selected 36 PT-NEC infants (gestational age 28.3 [25-35.6] weeks vs. 38.6 [31.7-40.7] weeks). Postnatal age at onset was significantly lower in CHD-NEC patients (4 [2-24] vs. 11 [4-41] days, p <0.001). Lowest pH levels were lower (7.21 [7.01-7.47] vs. 7.27 [6.68-7.39], p = 0.02), and highest CRP levels were higher (112.5 mg/L [5.0-425.0] vs. 66.0 [52-189.0], p = 0.05) in PT-NEC vs. CHD-NEC. Anatomic localisation of the disease differed: the colon was significantly more often involved in CHD-NEC versus PT-NEC (86% vs. 33%, p = 0.03). Mortality caused by NEC was not different (22% vs. 11%, p = 0.47). Conclusion: While outcome of NEC in both groups is similar, the predominant NEC localisation differed between CHD-NEC and PT-NEC patients. This suggests that both variants of the disease have a different underlying pathophysiological mechanism that predisposes different intestinal regions to develop NEC. Type of Study: Retrospective Case-Control Study. (C) 2018 Elsevier Inc. All rights reserved.
Necrotizing Enterocolitis Associated with Congenital Heart Disease:a Different Entity?
Background: Necrotizing enterocolitis (NEC) predominantly occurs in preterm infants (PT-NEC). In term neonates, NEC occurs more frequently when a congenital heart disease is present (CHDNEC). Our aim was to evaluate differences and similarities in disease characteristics of PT-NEC versus CHD-NEC. Methods: In this retrospective case-control study we identified all CHD infants who developed NEC Bell's stage >= 2 in our center from 2004 to 2014. We randomly selected (1:2 ratio) PT-NEC infants from the same period. Biochemical and clinical variables were retrieved from patient files. Results: We found 18 CHD-NEC infants and selected 36 PT-NEC infants (gestational age 28.3 [25-35.6] weeks vs. 38.6 [31.7-40.7] weeks). Postnatal age at onset was significantly lower in CHD-NEC patients (4 [2-24] vs. 11 [4-41] days, p <0.001). Lowest pH levels were lower (7.21 [7.01-7.47] vs. 7.27 [6.68-7.39], p = 0.02), and highest CRP levels were higher (112.5 mg/L [5.0-425.0] vs. 66.0 [52-189.0], p = 0.05) in PT-NEC vs. CHD-NEC. Anatomic localisation of the disease differed: the colon was significantly more often involved in CHD-NEC versus PT-NEC (86% vs. 33%, p = 0.03). Mortality caused by NEC was not different (22% vs. 11%, p = 0.47). Conclusion: While outcome of NEC in both groups is similar, the predominant NEC localisation differed between CHD-NEC and PT-NEC patients. This suggests that both variants of the disease have a different underlying pathophysiological mechanism that predisposes different intestinal regions to develop NEC. Type of Study: Retrospective Case-Control Study. (C) 2018 Elsevier Inc. All rights reserved.
Necrotizing Enterocolitis Associated with Congenital Heart Disease:a Different Entity?
Bubberman, J M (author) / van Zoonen, A (author) / Bruggink, J L M (author) / van der Heide, M (author) / Berger, R M F (author) / Bos, A F (author) / Kooi, E M W (author) / Hulscher, J B F (author)
2019-09-01
Bubberman , J M , van Zoonen , A , Bruggink , J L M , van der Heide , M , Berger , R M F , Bos , A F , Kooi , E M W & Hulscher , J B F 2019 , ' Necrotizing Enterocolitis Associated with Congenital Heart Disease : a Different Entity? ' , Journal of Pediatric Surgery , vol. 54 , no. 9 , pp. 1755-1760 . https://doi.org/10.1016/j.jpedsurg.2018.11.012
Article (Journal)
Electronic Resource
English
RISK , ISCHEMIA , Congenital heart disease , CHD , NEC , Prematurity , MORTALITY , RIGHT COLON , Necrotising enterocolitis , INFANTS
Necrotizing enterocolitis: an editorial
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Diagnostic imaging in necrotizing enterocolitis
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