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Diagnostic utility of fecal calprotectin as a biomarker of gut inflammation in neonates to predict necrotizing enterocolitis: A prospective study
Background: Necrotizing enterocolitis (NEC) is a neonatal emergency that affects preterm newborns during the 1st weeks of life.Diagnosis is made mainly by clinical criteria since no specific diagnostic tests are available. Objective: The objective was to evaluatefecal calprotectin (fCal) as a biomarker of gut inflammation to predict NEC in preterm neonates. Methods: Design: Diagnostic testevaluation. Inclusion criteria: 102 preterm neonates <36 weeks gestation and within 7 days of birth admitted in Level III neonatalintensive care unit (NICU) were recruited from January 2010 to May 2011. Exclusion criteria: Congenital anomalies and overt infection.Paired stool samples at day 3 and 7 were analyzed by lateral quantum blue rapid calprotectin assay. Cut-off values of fCal weredetermined among 30 term healthy infants. A structured questionnaire which included gestational age, symptoms at admission, andmodified Bell’s staging was used to record NEC episodes on day 3 and 7 of admission. Septic screen and radiological tools were doneas per NICU protocol. Results: 48% were above 34 weeks gestation; 31.3% were of very low birth weight. As per modified Bell’sstaging on day 3 and 7, 22 and 11 neonates had 1a or above stage, respectively. 15 had features of NEC; of these, 12 were managedappropriately and discharged and 3 died. In the receiver-operated curve with fCal >279 μg/g as cutoff, the area under the curve was0.652 (95% confidence interval: 0.516-0.789). Day 3 fCal levels were high in 65.7% neonates. Using NEC as outcome, sensitivity of thetest was 93.3%; specificity was 39%; positive predictive value was 20.8% and negative predictive value was 97.14%. Conclusion: fCalhas high sensitivity for diagnosing NEC in preterm neonates. However, further research is needed to establish its clinical usefulness.
Diagnostic utility of fecal calprotectin as a biomarker of gut inflammation in neonates to predict necrotizing enterocolitis: A prospective study
Background: Necrotizing enterocolitis (NEC) is a neonatal emergency that affects preterm newborns during the 1st weeks of life.Diagnosis is made mainly by clinical criteria since no specific diagnostic tests are available. Objective: The objective was to evaluatefecal calprotectin (fCal) as a biomarker of gut inflammation to predict NEC in preterm neonates. Methods: Design: Diagnostic testevaluation. Inclusion criteria: 102 preterm neonates <36 weeks gestation and within 7 days of birth admitted in Level III neonatalintensive care unit (NICU) were recruited from January 2010 to May 2011. Exclusion criteria: Congenital anomalies and overt infection.Paired stool samples at day 3 and 7 were analyzed by lateral quantum blue rapid calprotectin assay. Cut-off values of fCal weredetermined among 30 term healthy infants. A structured questionnaire which included gestational age, symptoms at admission, andmodified Bell’s staging was used to record NEC episodes on day 3 and 7 of admission. Septic screen and radiological tools were doneas per NICU protocol. Results: 48% were above 34 weeks gestation; 31.3% were of very low birth weight. As per modified Bell’sstaging on day 3 and 7, 22 and 11 neonates had 1a or above stage, respectively. 15 had features of NEC; of these, 12 were managedappropriately and discharged and 3 died. In the receiver-operated curve with fCal >279 μg/g as cutoff, the area under the curve was0.652 (95% confidence interval: 0.516-0.789). Day 3 fCal levels were high in 65.7% neonates. Using NEC as outcome, sensitivity of thetest was 93.3%; specificity was 39%; positive predictive value was 20.8% and negative predictive value was 97.14%. Conclusion: fCalhas high sensitivity for diagnosing NEC in preterm neonates. However, further research is needed to establish its clinical usefulness.
Diagnostic utility of fecal calprotectin as a biomarker of gut inflammation in neonates to predict necrotizing enterocolitis: A prospective study
Shenoy, Mohan T (author) / Shenoy, K T (author) / Roseth, A (author) / Geir, Larsson (author) / Keshavamurthy, S R (author)
2017-11-29
Indian Journal of Child Health; Volume 1, Issue 3, Oct - Dec 2014; 99-104 ; 2349-6126 ; 2349-6118
Article (Journal)
Electronic Resource
English
Diagnostic imaging in necrotizing enterocolitis
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