ABSTRAK Perilaku rangka beton bertulang dengan dinding pengisi berlubang sentris (RDP) dipengaruhi oleh karakteristik material dan geometrinya. Analisis sensitivitas dilakukan pada model RDP menggunakan analisis numerik akibat variasi modulus elastisitas dinding (Em), modulus elastisitas beton (Ec), dan lebar strat diagonal (wds) pada struktur RDP. Balok dan kolom dimodel sebagai elemen frame dan dinding pengisi berlubang dimodel sebagai strat diagonal. Hasil analisis sensitivitas model RDP kemudian dibandingkan dengan hasil eksperimen peneliti lain dan diaplikasikan pada gedung perkantoran 3 lantai. Hasil analisis sensitivitas menunjukkan bahwa nilai modulus elastisitas dinding (Em), modulus elastisitas beton (Ec), dan Inersia balok (Ib) dan inersia kolom (Ik) perlu direduksi setelah 95% beban lateral dikerjakan pada struktur. Nilai reduksi pada beban 95% adalah sebesar 0,6 dan 0,8 masing-masing untuk modulus elastisitas dan inersia. Pada beban 100%, nilai modulus dan inersia dinding pengisi masing-masing direduksi sebesar 0,5 dan 0,7. Lebar strat diagonal (wds) yang digunakan dalam analisis yaitu Persamaan 1. Hasil analisis pada gedung menunjukkan bahwa peningkatan beban dari 95% ke 100% dan reduksi modulus elastisitas serta inersia, mengakibatkan peningkatan simpangan struktur, terjadi penurunan momen lapangan pada balok sebesar 4,74%-11,22%, dan penurunan momen tumpuan pada balok sebesar 12,84%-14,15%. Pada kolom, terjadi penurunan momen sebesar 1,24%-17,94%. Penurunan gaya geser pada balok terjadi sebesar 0,97%-1,63%, sedangkan pada kolom sebesar 1,67%-4,84%, namun terjadi peningkatan gaya aksial pada kolom sebesar 4,03%-5,36%. ; ABSTRACT Research on the sensitivity analysis of RC Infilled Frame stucture using numerical analysis has been done by varying the modulus of elasticity of the wall (Em), modulus of elasticity of the concrete (Ec), and diagonal strut width (wds). The frames were modeled using frame elements and the infill walls with opening were modeled using diagonal strut. The results of sensitivity analysis were then applied to 3-story office building models. The reinforced concrete building was of three-spans in which a perforated infill wall with an opening ratio of 10% - 60% was added in its middle span. A total of 42 models were created and loaded with a combination of vertical and seismic loads to compare its lateral displacements and internal forces. The results of the sensitivity analysis show that the value of the the modulus of elasticity of the wall (Em), modulus of elasticity of the concrete (Ec), and the inertia of the beams and columns (Ib and Ik) need to be reduced when the load of 95% or higher were applied. The reduction factor applied at 95% load was 0.6 and 0.8 for the elastic modulus and inertia, respectively. At 100% load, the modulus value and inertia of the infill walls were 0.5 and 0.7, respectively. Diagonal strut width (wds) used in the analyses was Equation 1. The results of the analysis showed that increasing the loads from 95% to 100% load while reducing the modulus and inertia, resulted in a decrease of positive moment of the beam by 4.74%-11.22% and also a decrease of negative moment of the beam by 12.84%-14.15%. For the column, there was a decrease of moment ranged 1.24%-17.94%. The decrease of shear force on beam is 0.97%-1.63%, while in the column there is a decrease of shear force between 1.67% and 4.84%, in contrast, an increase in axial forces occur in the column by 4.03%-5.36%