A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Nešiklių prigimties bei fizinių ir cheminių aktyviklių įtakos amorolfino ir naftifino pernašai į žmogaus nagą vertinimas ; Evaluation of carrier type, physical and chemical enhancers for transungual delivery of amorolfine and naftifine
Topical treatment of onychomycosis is complicated by the structure of the nail, one of the strongest hydrophilic barriers in the human body. Keratin molecules are linked by disulfide bonds, which determine the strength of the nail plate and the limited permeability of lipophilic substances. In this research, two antifungal agents were selected: amorolfine and naftifine. The hydrophilic properties of nail and the lipophilicity of antifungal agents result in limited penetration into deeper nail layers. In order to improve the possibilities of modifying the penetration into the nail, the application of carriers: nail lacquers and microemulsions was evaluated. During formulation, it is important to assess carriers’ ability to release active substances and their suitability for penetration of substances into the nail. The results of the biopharmaceutical studies allowed to evaluate the appropriateness of formulations and to determine the distribution of active substances in human nails. In assessing the influence of chemical and physical agents on penetration processes, an interacting effect of laser and thioglycolic acid, which increases accumulation of amorolfine and naftifine and permeation through the nail, has been established. Evaluating the outcomes of formulations to human nail in vitro and ex vivo studies allows predicting the effectiveness of formulated systems on the surface of the nail and effectively controlling the quality of the developed products. The objectives of the study. 1. To model different dosage forms of amorolfine and naftifine used on the nail, to optimize their composition and evaluate quality. 2. To evaluate the kinetics of amorolfine and naftifine release from experimental nail lacquers formulations and determine drug penetration from microemulsions into human nail plate layers. 3. To evaluate the influence of chemical enhancers on the accumulation of amorolfine and naftifine in the bovine hooves as a nail system and selected enhancers compatibility with the components of optimized formulation. 4. To evaluate the effect of physical enhancers on the accumulation of amorolfine and naftifine in the human nail. 5. To evaluate the influence of physical and chemical enhancers combi-nation on the permeability of amorolfine and naftifine into human nail
Nešiklių prigimties bei fizinių ir cheminių aktyviklių įtakos amorolfino ir naftifino pernašai į žmogaus nagą vertinimas ; Evaluation of carrier type, physical and chemical enhancers for transungual delivery of amorolfine and naftifine
Topical treatment of onychomycosis is complicated by the structure of the nail, one of the strongest hydrophilic barriers in the human body. Keratin molecules are linked by disulfide bonds, which determine the strength of the nail plate and the limited permeability of lipophilic substances. In this research, two antifungal agents were selected: amorolfine and naftifine. The hydrophilic properties of nail and the lipophilicity of antifungal agents result in limited penetration into deeper nail layers. In order to improve the possibilities of modifying the penetration into the nail, the application of carriers: nail lacquers and microemulsions was evaluated. During formulation, it is important to assess carriers’ ability to release active substances and their suitability for penetration of substances into the nail. The results of the biopharmaceutical studies allowed to evaluate the appropriateness of formulations and to determine the distribution of active substances in human nails. In assessing the influence of chemical and physical agents on penetration processes, an interacting effect of laser and thioglycolic acid, which increases accumulation of amorolfine and naftifine and permeation through the nail, has been established. Evaluating the outcomes of formulations to human nail in vitro and ex vivo studies allows predicting the effectiveness of formulated systems on the surface of the nail and effectively controlling the quality of the developed products. The objectives of the study. 1. To model different dosage forms of amorolfine and naftifine used on the nail, to optimize their composition and evaluate quality. 2. To evaluate the kinetics of amorolfine and naftifine release from experimental nail lacquers formulations and determine drug penetration from microemulsions into human nail plate layers. 3. To evaluate the influence of chemical enhancers on the accumulation of amorolfine and naftifine in the bovine hooves as a nail system and selected enhancers compatibility with the components of optimized formulation. 4. To evaluate the effect of physical enhancers on the accumulation of amorolfine and naftifine in the human nail. 5. To evaluate the influence of physical and chemical enhancers combi-nation on the permeability of amorolfine and naftifine into human nail
Nešiklių prigimties bei fizinių ir cheminių aktyviklių įtakos amorolfino ir naftifino pernašai į žmogaus nagą vertinimas ; Evaluation of carrier type, physical and chemical enhancers for transungual delivery of amorolfine and naftifine
Šveikauskaitė, Indrė (author) / Briedis, Vitalis
2019-08-30
Theses
Electronic Resource
Lithuanian , English
DDC:
690
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