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Phenotypical characterization of sex-dependent traits in mice models of hyperthyroidism and hypothyroidism ; Phänotypische Charakterisierung von geschlechtsabhängigen Merkmalen einer Hyperthyreose und Hypothyreose im Mausmodell
It is well known, that the clinical situation of thyroid dysfunctions (TDs), hyper- and hypothyroidism have an increased preponderance in women than men. In contrast, a sex-specific outcome of hyper- and hypothyroidism has not been characterized yet. Moreover, the prevalence of TDs increase with age, with unknown sex-specific consequences for the cardiovascular system, energy metabolism and behaviour. To mimic the clinical situation, first an in vivo mouse model for chronic hyperthyroidism in male and female mice was established, followed by induction of chronic hyper- and hypothyroidism of both sexes in young, adult and old aged mice. This allowed a comprehensive characterization of the interplay between sex and age on phenotypical traits of TD at different life stages and enabled the analysis of organ-specific thyroid hormone (TH) effects. Metabolic parameters of body weight change, food and water intake, TH serum concentrations, heart rate, body temperature, muscle function and activity were assessed. In young mice a distinct sex impact on TH-dependent alterations was identified for body weight, body temperature, nutrient intake, TH serum concentrations and neuromuscular features. In comparison to adult and old age groups sex-effects were persistent (for body temperature, TH serum concentrations, activity) and exaggerated (for body weight and muscle function), whereas no TH-dependent differences between male and female mice were noted for heart rate at any age. Molecular investigations showed less sex influence on TH-dependent gene expression in heart, whereas in brown adipose tissue and even more significant alterations in liver were detected. Further analysis of a sex and TH-dependent regulation of Claudin-1 in livers of mice indicated relevance in an altered biliary homeostasis and a possible pathophysiological role for TH-dependent change of sex-dependency in cholelithiasis. To conclude, these studies allow a comprehensive analysis of sex influence on phenotypical and molecular traits of hyper- and ...
Phenotypical characterization of sex-dependent traits in mice models of hyperthyroidism and hypothyroidism ; Phänotypische Charakterisierung von geschlechtsabhängigen Merkmalen einer Hyperthyreose und Hypothyreose im Mausmodell
It is well known, that the clinical situation of thyroid dysfunctions (TDs), hyper- and hypothyroidism have an increased preponderance in women than men. In contrast, a sex-specific outcome of hyper- and hypothyroidism has not been characterized yet. Moreover, the prevalence of TDs increase with age, with unknown sex-specific consequences for the cardiovascular system, energy metabolism and behaviour. To mimic the clinical situation, first an in vivo mouse model for chronic hyperthyroidism in male and female mice was established, followed by induction of chronic hyper- and hypothyroidism of both sexes in young, adult and old aged mice. This allowed a comprehensive characterization of the interplay between sex and age on phenotypical traits of TD at different life stages and enabled the analysis of organ-specific thyroid hormone (TH) effects. Metabolic parameters of body weight change, food and water intake, TH serum concentrations, heart rate, body temperature, muscle function and activity were assessed. In young mice a distinct sex impact on TH-dependent alterations was identified for body weight, body temperature, nutrient intake, TH serum concentrations and neuromuscular features. In comparison to adult and old age groups sex-effects were persistent (for body temperature, TH serum concentrations, activity) and exaggerated (for body weight and muscle function), whereas no TH-dependent differences between male and female mice were noted for heart rate at any age. Molecular investigations showed less sex influence on TH-dependent gene expression in heart, whereas in brown adipose tissue and even more significant alterations in liver were detected. Further analysis of a sex and TH-dependent regulation of Claudin-1 in livers of mice indicated relevance in an altered biliary homeostasis and a possible pathophysiological role for TH-dependent change of sex-dependency in cholelithiasis. To conclude, these studies allow a comprehensive analysis of sex influence on phenotypical and molecular traits of hyper- and ...
Phenotypical characterization of sex-dependent traits in mice models of hyperthyroidism and hypothyroidism ; Phänotypische Charakterisierung von geschlechtsabhängigen Merkmalen einer Hyperthyreose und Hypothyreose im Mausmodell
Rakov, Helena (author) / Führer-Sakel, Dagmar
2017-07-20
Theses
Electronic Resource
English
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