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The locus coeruleus: the central relay between neuronal network activation and sympathetic responses in cognitive control
The ability of humans to integrate different body processes is most important for survival. The neuro-visceral integration model suggests that both cognitions and emotions are regulated by superior brain systems also involved in the regulation of autonomic function. Therefore, cognitive performance and affective processing is closely linked to autonomic responses. In order to improve the understanding of human behavior and associated dysfunctions, we need to acquire a better understanding of the interplay between the central nervous system (CNS) and peripheral autonomic nervous system (ANS) in cognitive control. A pivotal role of the noradrenergic neurotransmitter system in cognitive control has been suggested. In the present thesis, functional fMRI was used to expand our knowledge of the brain body interaction in cognitive control with the locus coeruleus (LC), which is the main production site of noradrenaline in the brain, as central relay nucleus. Broad functional connections of the LC to cortical and subcortical regions predominantly involved in executive function were found. The paramount importance of the LC in cognitive control was emphasized by an increase of its activation proportional to the increase of cognitive load. In patients with schizophrenia, this relation was absent indicating a deficient role of the LC-noradrenergic system. Furthermore, LC BOLD activation was associated with pupillary dilation which supports the interpretation of the LC playing a pivotal role in controlling sympathetic autonomic function. With these findings, I was able to link the cognitive control network to the sympathetic nervous system with the LC as central relay nucleus. Thus, the present thesis contributes to an extension of the current state-of-the-art in neuropsychology. ; Die Fähigkeit des menschlichen Körpers verschiedenste Prozesse zu integrieren garantiert das Überleben. Das Neuroviszerale Integrationsmodell geht davon aus, dass Kognitionen sowie Emotionen von übergeordneten kortikalen Netzwerken reguliert ...
The locus coeruleus: the central relay between neuronal network activation and sympathetic responses in cognitive control
The ability of humans to integrate different body processes is most important for survival. The neuro-visceral integration model suggests that both cognitions and emotions are regulated by superior brain systems also involved in the regulation of autonomic function. Therefore, cognitive performance and affective processing is closely linked to autonomic responses. In order to improve the understanding of human behavior and associated dysfunctions, we need to acquire a better understanding of the interplay between the central nervous system (CNS) and peripheral autonomic nervous system (ANS) in cognitive control. A pivotal role of the noradrenergic neurotransmitter system in cognitive control has been suggested. In the present thesis, functional fMRI was used to expand our knowledge of the brain body interaction in cognitive control with the locus coeruleus (LC), which is the main production site of noradrenaline in the brain, as central relay nucleus. Broad functional connections of the LC to cortical and subcortical regions predominantly involved in executive function were found. The paramount importance of the LC in cognitive control was emphasized by an increase of its activation proportional to the increase of cognitive load. In patients with schizophrenia, this relation was absent indicating a deficient role of the LC-noradrenergic system. Furthermore, LC BOLD activation was associated with pupillary dilation which supports the interpretation of the LC playing a pivotal role in controlling sympathetic autonomic function. With these findings, I was able to link the cognitive control network to the sympathetic nervous system with the LC as central relay nucleus. Thus, the present thesis contributes to an extension of the current state-of-the-art in neuropsychology. ; Die Fähigkeit des menschlichen Körpers verschiedenste Prozesse zu integrieren garantiert das Überleben. Das Neuroviszerale Integrationsmodell geht davon aus, dass Kognitionen sowie Emotionen von übergeordneten kortikalen Netzwerken reguliert ...
The locus coeruleus: the central relay between neuronal network activation and sympathetic responses in cognitive control
Köhler, Stefanie (author) / Weiß, Thomas / Schweinberger, Stefan R. / Bär, Karl-Jürgen
2019-01-01
Theses
Electronic Resource
English
Doktorarbeit , Kognition , thesis , ddc:150
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