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Selective Reduction of Dimedone
The selective hydrogenation of dimedone (1) to the corresponding monoketone 2 over palladium and Amberlyst 15® is reported. The product is a synthetic building block for the fragrance and pharmaceutical industry. Advantages of the new catalytic procedure are the high catalyst activity and selectivity, less by-product formation, avoidance of the presence of acid, and consequently, less salt formation due to the omission of a neutralization step. Using a substrate/catalyst ratio of >100 compound 2 can be synthesized in 97% yield at full conversion. Recycling of the catalyst several times has been shown to be feasible without any detectable decrease in selectivity.
Selective Reduction of Dimedone
The selective hydrogenation of dimedone (1) to the corresponding monoketone 2 over palladium and Amberlyst 15® is reported. The product is a synthetic building block for the fragrance and pharmaceutical industry. Advantages of the new catalytic procedure are the high catalyst activity and selectivity, less by-product formation, avoidance of the presence of acid, and consequently, less salt formation due to the omission of a neutralization step. Using a substrate/catalyst ratio of >100 compound 2 can be synthesized in 97% yield at full conversion. Recycling of the catalyst several times has been shown to be feasible without any detectable decrease in selectivity.
Selective Reduction of Dimedone
Werner Bonrath (author) / Ulla Létinois (author)
2009
Article (Journal)
Electronic Resource
Unknown
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