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Total mercury concentration in placental tissue, a good biomarker of prenatal mercury exposure, is associated with risk for neural tube defects in offspring
Objective: To examine the role of total mercury (T-Hg) in placenta as a biomarker of prenatal mercury (Hg) exposure and determine the association between prenatal Hg exposure and risk for neural tube defects (NTDs) in offspring. Methods: Total Hg concentrations in placental tissue were detected in 408 NTD cases and 593 healthy controls enrolled in Shanxi province in northern China. Methylmercury (MeHg) and T-Hg were also detected in the umbilical cord of 147 NTD cases and 140 healthy controls. In addition, MeHg and T-Hg were detected in fetal kidney, liver, and brain tissues of 51 NTD cases. Spearman’s rank correlation (rs) was used to evaluate the correlations between placental T-Hg and T-Hg in umbilical cord and fetal kidney, liver, and brain tissues. The Wilcoxon rank-sum test was used to compare T-Hg amounts between case and control groups. Logistic regression was used to examine the association between placental T-Hg and risk for NTDs. Results: Placental T-Hg was significantly correlated with T-Hg in umbilical cord (rs = 0.479), kidney (rs = 0.718), liver (rs = 0.656), and brain (rs = 0.512) tissues (all p < 0.001). The median (25th percentile–75th percentile) concentration for placental T-Hg in the NTD case group was 8.91 (5.00–17.1) ng/g dry weight (d.w.), significantly higher than that in the healthy control group (4.99 [3.26–7.93] ng/g d.w., p < 0.001). After adjusting for potential confounders, higher levels of T-Hg in placenta were associated with increased risk for NTDs in offspring (OR = 1.76, 95% CI: 1.13–2.76), and a dose–response relationship was found (p < 0.001). Conclusion: The concentration of T-Hg in placenta is a good biomarker for estimating prenatal Hg exposure, which is associated with increased risk for NTDs.
Total mercury concentration in placental tissue, a good biomarker of prenatal mercury exposure, is associated with risk for neural tube defects in offspring
Objective: To examine the role of total mercury (T-Hg) in placenta as a biomarker of prenatal mercury (Hg) exposure and determine the association between prenatal Hg exposure and risk for neural tube defects (NTDs) in offspring. Methods: Total Hg concentrations in placental tissue were detected in 408 NTD cases and 593 healthy controls enrolled in Shanxi province in northern China. Methylmercury (MeHg) and T-Hg were also detected in the umbilical cord of 147 NTD cases and 140 healthy controls. In addition, MeHg and T-Hg were detected in fetal kidney, liver, and brain tissues of 51 NTD cases. Spearman’s rank correlation (rs) was used to evaluate the correlations between placental T-Hg and T-Hg in umbilical cord and fetal kidney, liver, and brain tissues. The Wilcoxon rank-sum test was used to compare T-Hg amounts between case and control groups. Logistic regression was used to examine the association between placental T-Hg and risk for NTDs. Results: Placental T-Hg was significantly correlated with T-Hg in umbilical cord (rs = 0.479), kidney (rs = 0.718), liver (rs = 0.656), and brain (rs = 0.512) tissues (all p < 0.001). The median (25th percentile–75th percentile) concentration for placental T-Hg in the NTD case group was 8.91 (5.00–17.1) ng/g dry weight (d.w.), significantly higher than that in the healthy control group (4.99 [3.26–7.93] ng/g d.w., p < 0.001). After adjusting for potential confounders, higher levels of T-Hg in placenta were associated with increased risk for NTDs in offspring (OR = 1.76, 95% CI: 1.13–2.76), and a dose–response relationship was found (p < 0.001). Conclusion: The concentration of T-Hg in placenta is a good biomarker for estimating prenatal Hg exposure, which is associated with increased risk for NTDs.
Total mercury concentration in placental tissue, a good biomarker of prenatal mercury exposure, is associated with risk for neural tube defects in offspring
Mingkun Tong (author) / Jingru Yu (author) / Ming Liu (author) / Zhiwen Li (author) / Linlin Wang (author) / Chenghong Yin (author) / Aiguo Ren (author) / Laiguo Chen (author) / Lei Jin (author)
2021
Article (Journal)
Electronic Resource
Unknown
Fetus , Placenta , Mercury , Brain , Neural tube defects , Kidney , Environmental sciences , GE1-350
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