A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Epigenetic toxicity of heavy metals − implications for embryonic stem cells
Exposure to heavy metals, such as cadmium, nickel, mercury, arsenic, lead, and hexavalent chromium has been linked to dysregulated developmental processes, such as impaired stem cell differentiation. Heavy metals are well-known modifiers of the epigenome. Stem and progenitor cells are particularly vulnerable to exposure to potentially toxic metals since these cells rely on epigenetic reprogramming for their proper functioning. Therefore, exposure to metals can impair stem and progenitor cell proliferation, pluripotency, stemness, and differentiation. In this review, we provide a comprehensive summary of current evidence on the epigenetic effects of heavy metals on stem cells, focusing particularly on DNA methylation and histone modifications. Moreover, we explore the underlying mechanisms responsible for these epigenetic changes. By providing an overview of heavy metal exposure-induced alterations to the epigenome, the underlying mechanisms, and the consequences of those alterations on stem cell function, this review provides a foundation for further research in this critical area of overlap between toxicology and developmental biology.
Epigenetic toxicity of heavy metals − implications for embryonic stem cells
Exposure to heavy metals, such as cadmium, nickel, mercury, arsenic, lead, and hexavalent chromium has been linked to dysregulated developmental processes, such as impaired stem cell differentiation. Heavy metals are well-known modifiers of the epigenome. Stem and progenitor cells are particularly vulnerable to exposure to potentially toxic metals since these cells rely on epigenetic reprogramming for their proper functioning. Therefore, exposure to metals can impair stem and progenitor cell proliferation, pluripotency, stemness, and differentiation. In this review, we provide a comprehensive summary of current evidence on the epigenetic effects of heavy metals on stem cells, focusing particularly on DNA methylation and histone modifications. Moreover, we explore the underlying mechanisms responsible for these epigenetic changes. By providing an overview of heavy metal exposure-induced alterations to the epigenome, the underlying mechanisms, and the consequences of those alterations on stem cell function, this review provides a foundation for further research in this critical area of overlap between toxicology and developmental biology.
Epigenetic toxicity of heavy metals − implications for embryonic stem cells
Nicholas Kim (author) / David Filipovic (author) / Sudin Bhattacharya (author) / Suresh Cuddapah (author)
2024
Article (Journal)
Electronic Resource
Unknown
Metadata by DOAJ is licensed under CC BY-SA 1.0
Epigenetic toxicity of heavy metals − implications for embryonic stem cells
| Elsevier | 2024
Vitrification of Human Embryonic Stem Cells
| British Library Online Contents | 2005
Embryonic Stem Cells: From Markers to Market
| British Library Online Contents | 2008
Rejuvenation of Adult Stem Cells: Is Age-Associated Dysfunction Epigenetic?
British Library Online Contents | 2013
Embryonic stem cells: a novel paradigm to study proteostasis?
| British Library Online Contents | 2017