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Swelling, mechanical and mucoadhesion properties of Mt/starch-g-PMAA nanocomposite hydrogels
Abstract Novel mucoadhesive montmorillonite/starch-graft-poly (methacrylic acid) nanocomposite hydrogels (Mt/S-g-PMAA) based on gelatinized wheat starch, an anionic monomer methacrylic acid (MAA), and different amounts of montmorillonite (Mt) as nanoparticles were synthesized according to the conventional grafting reaction mechanism in the aqueous media. The grafting amount of the products (G%) was determined. The formation of Mt/S-g-PMAA was confirmed by FTIR and XRD analyses. The swelling behavior and the erosion characteristics of the Mt/S-g-PMAA were investigated in deionized water, and pH=5 lactate buffer solution as in vitro vaginal medium at 37±0,1ºC. Mechanical and in vitro mucoadhesion properties of all Mt/S-g-PMAA were also investigated using ewe vaginal mucosa. The results show that adding a higher amount of Mt could effectively increase the mucoadhesion properties of the clay mineral-polymer nanocomposite (CPN) hydrogels. It is then concluded that the 10Mt/S-g-PMAA may be used as alternative highly mucoadhesive CPN hydrogel drug carrier for vaginal route.
Highlights Mucoadhesive PMAA grafted starch CPN was synthesized for the first time. The amount of Mt affects mucoadhesion of CPN hydrogel. The amount of Mt affects grafting amount of CPN hydrogel. CPN hydrogel possesses excellent mucoadhesion for ewe vaginal mucosa.
Swelling, mechanical and mucoadhesion properties of Mt/starch-g-PMAA nanocomposite hydrogels
Abstract Novel mucoadhesive montmorillonite/starch-graft-poly (methacrylic acid) nanocomposite hydrogels (Mt/S-g-PMAA) based on gelatinized wheat starch, an anionic monomer methacrylic acid (MAA), and different amounts of montmorillonite (Mt) as nanoparticles were synthesized according to the conventional grafting reaction mechanism in the aqueous media. The grafting amount of the products (G%) was determined. The formation of Mt/S-g-PMAA was confirmed by FTIR and XRD analyses. The swelling behavior and the erosion characteristics of the Mt/S-g-PMAA were investigated in deionized water, and pH=5 lactate buffer solution as in vitro vaginal medium at 37±0,1ºC. Mechanical and in vitro mucoadhesion properties of all Mt/S-g-PMAA were also investigated using ewe vaginal mucosa. The results show that adding a higher amount of Mt could effectively increase the mucoadhesion properties of the clay mineral-polymer nanocomposite (CPN) hydrogels. It is then concluded that the 10Mt/S-g-PMAA may be used as alternative highly mucoadhesive CPN hydrogel drug carrier for vaginal route.
Highlights Mucoadhesive PMAA grafted starch CPN was synthesized for the first time. The amount of Mt affects mucoadhesion of CPN hydrogel. The amount of Mt affects grafting amount of CPN hydrogel. CPN hydrogel possesses excellent mucoadhesion for ewe vaginal mucosa.
Swelling, mechanical and mucoadhesion properties of Mt/starch-g-PMAA nanocomposite hydrogels
Güler, Mehmet Ali (author) / Gök, Mehmet Koray (author) / Figen, Aysel Kantürk (author) / Özgümüş, Saadet (author)
Applied Clay Science ; 112-113 ; 44-52
2015-04-26
9 pages
Article (Journal)
Electronic Resource
English
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