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One-pot template-free fabrication of hollow mesoporous sodalite nanospheres for drug release
Abstract Hollow mesoporous sodalite nanospheres (HMSN) were facilely fabricated by a one-pot template-free hydrothermal route using natural halloysite as a silicon–aluminum source. The obtained products were characterized by X-ray diffraction, Fourier transform infrared spectrum, transmission electron microscope, field emission scanning electron microscope and N2 adsorption–desorption isotherm. Well-defined HMSN with a mesopore structure were successfully obtained when the hydrothermal temperature was 180°C, the reaction time was 9h and the NaOH concentration was 3mol/L. The products began to gradually transform from HMSN to micro-nepheline hydrate when the time was extended to 12h. The drug release results indicate that the modified HMSN have outstanding drug release performance. The capacity for aspirin loading can reach as high as 20.8% and its cumulative release can reach 65% when release time is ~50h.
Graphical abstract Display Omitted
Highlights Natural halloysite nanotubes are considered as a Si–Al source to prepare HMSN. HMSN with a mesopore size of 3nm were fabricated by a one-pot template-free route. The products gradually transform from halloysite to HMSN, and then to nepheline. The HMSN show excellent drug release in comparison with halloysite and nepheline.
One-pot template-free fabrication of hollow mesoporous sodalite nanospheres for drug release
Abstract Hollow mesoporous sodalite nanospheres (HMSN) were facilely fabricated by a one-pot template-free hydrothermal route using natural halloysite as a silicon–aluminum source. The obtained products were characterized by X-ray diffraction, Fourier transform infrared spectrum, transmission electron microscope, field emission scanning electron microscope and N2 adsorption–desorption isotherm. Well-defined HMSN with a mesopore structure were successfully obtained when the hydrothermal temperature was 180°C, the reaction time was 9h and the NaOH concentration was 3mol/L. The products began to gradually transform from HMSN to micro-nepheline hydrate when the time was extended to 12h. The drug release results indicate that the modified HMSN have outstanding drug release performance. The capacity for aspirin loading can reach as high as 20.8% and its cumulative release can reach 65% when release time is ~50h.
Graphical abstract Display Omitted
Highlights Natural halloysite nanotubes are considered as a Si–Al source to prepare HMSN. HMSN with a mesopore size of 3nm were fabricated by a one-pot template-free route. The products gradually transform from halloysite to HMSN, and then to nepheline. The HMSN show excellent drug release in comparison with halloysite and nepheline.
One-pot template-free fabrication of hollow mesoporous sodalite nanospheres for drug release
Zuo, Shixiang (author) / Liu, Wenjie (author) / Yao, Chao (author) / Li, Xiazhang (author) / Luo, Shiping (author) / Wu, Fengqin (author) / Kong, Yong (author) / Liu, Xiaoheng (author)
Applied Clay Science ; 119 ; 170-174
2015-08-20
5 pages
Article (Journal)
Electronic Resource
English
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