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Multiple environmental exposures in early-life and allergy-related outcomes in childhood
Highlights Associations between early-life exposome and allergy-related outcomes were studied. No childhood exposures were associated with the allergy-related health outcomes. Prenatally, traffic variables, PMabs and phthalates were associated with rhinitis. Prenatally, traffic variables and phthalates were associated with itchy rash.
Abstract Introduction Early onset and high prevalence of allergic diseases result in high individual and socio-economic burdens. Several studies provide evidence for possible effects of environmental factors on allergic diseases, but these are mainly single-exposure studies. The exposome provides a novel holistic approach by simultaneously studying a large set of exposures. The aim of the study was to evaluate the association between a broad range of prenatal and childhood environmental exposures and allergy-related outcomes in children. Material and Methods Analyses of associations between 90 prenatal and 107 childhood exposures and allergy-related outcomes (last 12 months: rhinitis and itchy rash; ever: doctor-diagnosed eczema and food allergy) in 6–11 years old children (n = 1270) from the European Human Early-Life Exposome cohort were performed. Initially, we used an exposome-wide association study (ExWAS) considering the exposures independently, followed by a deletion-substitution-addition selection (DSA) algorithm considering all exposures simultaneously. All the exposure variables selected in the DSA were included in a final multi-exposure model using binomial general linear model (GLM). Results In ExWAS, no exposures were associated with the outcomes after correction for multiple comparison. In multi-exposure models for prenatal exposures, lower distance of residence to nearest road and higher di-iso-nonyl phthalate level were associated with increased risk of rhinitis, and particulate matter absorbance (PMabs) was associated with a decreased risk. Furthermore, traffic density on nearest road was associated with increased risk of itchy rash and diethyl phthalate with a reduced risk. DSA selected no associations of childhood exposures, or between prenatal exposures and eczema or food allergy. Discussion This first comprehensive and systematic analysis of many environmental exposures suggests that prenatal exposure to traffic-related variables, PMabs and phthalates are associated with rhinitis and itchy rash.
Multiple environmental exposures in early-life and allergy-related outcomes in childhood
Highlights Associations between early-life exposome and allergy-related outcomes were studied. No childhood exposures were associated with the allergy-related health outcomes. Prenatally, traffic variables, PMabs and phthalates were associated with rhinitis. Prenatally, traffic variables and phthalates were associated with itchy rash.
Abstract Introduction Early onset and high prevalence of allergic diseases result in high individual and socio-economic burdens. Several studies provide evidence for possible effects of environmental factors on allergic diseases, but these are mainly single-exposure studies. The exposome provides a novel holistic approach by simultaneously studying a large set of exposures. The aim of the study was to evaluate the association between a broad range of prenatal and childhood environmental exposures and allergy-related outcomes in children. Material and Methods Analyses of associations between 90 prenatal and 107 childhood exposures and allergy-related outcomes (last 12 months: rhinitis and itchy rash; ever: doctor-diagnosed eczema and food allergy) in 6–11 years old children (n = 1270) from the European Human Early-Life Exposome cohort were performed. Initially, we used an exposome-wide association study (ExWAS) considering the exposures independently, followed by a deletion-substitution-addition selection (DSA) algorithm considering all exposures simultaneously. All the exposure variables selected in the DSA were included in a final multi-exposure model using binomial general linear model (GLM). Results In ExWAS, no exposures were associated with the outcomes after correction for multiple comparison. In multi-exposure models for prenatal exposures, lower distance of residence to nearest road and higher di-iso-nonyl phthalate level were associated with increased risk of rhinitis, and particulate matter absorbance (PMabs) was associated with a decreased risk. Furthermore, traffic density on nearest road was associated with increased risk of itchy rash and diethyl phthalate with a reduced risk. DSA selected no associations of childhood exposures, or between prenatal exposures and eczema or food allergy. Discussion This first comprehensive and systematic analysis of many environmental exposures suggests that prenatal exposure to traffic-related variables, PMabs and phthalates are associated with rhinitis and itchy rash.
Multiple environmental exposures in early-life and allergy-related outcomes in childhood
Granum, Berit (author) / Oftedal, Bente (author) / Agier, Lydiane (author) / Siroux, Valerie (author) / Bird, Philippa (author) / Casas, Maribel (author) / Warembourg, Charline (author) / Wright, John (author) / Chatzi, Leda (author) / de Castro, Montserrat (author)
2020-08-03
Article (Journal)
Electronic Resource
English
Exposome , Environmental exposure , Allergic disease , Pregnancy , Childhood , BiB , Born in Bradford , BMI , Body mass index , BUPA , N-butyl paraben , DAGs , Directed acyclic graphs , DEP , Diethyl phthalate , DiNP , Di-<italic>iso</italic>-nonyl phthalate , DSA , Deletion-substitution-addition selection (DSA) , EDEN , Étude des Déterminants pré et postntals du development et de la santé de L’Énfant , ExWAS , Exposome-wide association study , GAM , Generalized linear models , GLM , General linear model , HELIX , The European Human Early-Life Exposome (HELIX) cohort , INMA , Infancia y Medio Ambiente , IQR , Interquartile range , KANC , Kaunus Cohort , MEP , Monoethyl phthalate , MoBa , Norwegian mother, father and childhood Study , NO<inf>2</inf> , Nitrogen dioxide , OR , Odds ratio , Oxo-MiNP , Mono-4-methyl-7-oxooctyl phthalate , PFHxS , Perfluorohexane sulfonate , PFOA , Perfluorooctanoate , PFOS , Perfluorooctane sulfonate , Particulate matter , PMabs , Particulate Matter absorbance , RHEA , RHEA Mother Child Cohort study , VIF , Variance inflation factor
Multiple environmental exposures in early-life and allergy-related outcomes in childhood
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