A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Adverse associations of long-term exposure to ambient ozone with molecular biomarkers of aging alleviated by residential greenness in rural Chinese adults
Graphical abstract Display Omitted
Highlights Exposure to high ozone levels was related to shortened TL and decreased mtDNA-CN. Residential greenness exposure was positively associated with TL and mtDNA-CN. Residential greenness attenuated the adverse effect of ozone on TL and mtDNA-CN.
Abstract Background Both ambient ozone exposure and residential greenness are linked to the aging process. However, their interactive effect on molecular biomarkers of aging (telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN)) remains unclear. Methods This study was conducted among 6418 rural Chinese adults. The concentration of ambient ozone was assessed using a random forest model. Residential greenness was represented by the normalized difference vegetation index (NDVI). Molecular biomarkers of aging (relative TL and relative mtDNA-CN) were determined by quantitative real-time polymerase chain reaction. Generalized linear regression models were applied to investigate the independent and combined effects of ambient ozone and residential greenness on relative TL and relative mtDNA-CN. Results The estimated percent changes and 95 % confidence intervals (CIs) of relative TL in response to per-unit increase in ambient ozone were –22.43 % (–23.74 %, −21.18 %), −14.19 % (−15.63 %, −12.72 %) and −4.50 % (−6.57 %, −2.27 %) for participants with low (NDVI ≤ 0.53), moderate (0.54–0.55) and high (≥0.56) residential greenness exposure, respectively, while the corresponding figures of relative mtDNA-CN were −12.63 % (−13.84 %, −11.31 %), −9.52 % (−10.60 %, −8.33 %) and 2.12 % (0.20 %, 4.19 %). Furthermore, negative interactive effects between ambient ozone and residential greenness exposure on molecular biomarkers of aging were observed (P for interaction < 0.001 for relative TL, and 0.098 for relative mtDNA-CN). Conclusions Long-term exposure to high concentrations of ambient ozone and low residential greenness was associated with decreased mtDNA-CN and shortened TL. The adverse effect of ambient ozone exposure on molecular biomarkers of aging may be attenuated by increased residential greenness.
Adverse associations of long-term exposure to ambient ozone with molecular biomarkers of aging alleviated by residential greenness in rural Chinese adults
Graphical abstract Display Omitted
Highlights Exposure to high ozone levels was related to shortened TL and decreased mtDNA-CN. Residential greenness exposure was positively associated with TL and mtDNA-CN. Residential greenness attenuated the adverse effect of ozone on TL and mtDNA-CN.
Abstract Background Both ambient ozone exposure and residential greenness are linked to the aging process. However, their interactive effect on molecular biomarkers of aging (telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN)) remains unclear. Methods This study was conducted among 6418 rural Chinese adults. The concentration of ambient ozone was assessed using a random forest model. Residential greenness was represented by the normalized difference vegetation index (NDVI). Molecular biomarkers of aging (relative TL and relative mtDNA-CN) were determined by quantitative real-time polymerase chain reaction. Generalized linear regression models were applied to investigate the independent and combined effects of ambient ozone and residential greenness on relative TL and relative mtDNA-CN. Results The estimated percent changes and 95 % confidence intervals (CIs) of relative TL in response to per-unit increase in ambient ozone were –22.43 % (–23.74 %, −21.18 %), −14.19 % (−15.63 %, −12.72 %) and −4.50 % (−6.57 %, −2.27 %) for participants with low (NDVI ≤ 0.53), moderate (0.54–0.55) and high (≥0.56) residential greenness exposure, respectively, while the corresponding figures of relative mtDNA-CN were −12.63 % (−13.84 %, −11.31 %), −9.52 % (−10.60 %, −8.33 %) and 2.12 % (0.20 %, 4.19 %). Furthermore, negative interactive effects between ambient ozone and residential greenness exposure on molecular biomarkers of aging were observed (P for interaction < 0.001 for relative TL, and 0.098 for relative mtDNA-CN). Conclusions Long-term exposure to high concentrations of ambient ozone and low residential greenness was associated with decreased mtDNA-CN and shortened TL. The adverse effect of ambient ozone exposure on molecular biomarkers of aging may be attenuated by increased residential greenness.
Adverse associations of long-term exposure to ambient ozone with molecular biomarkers of aging alleviated by residential greenness in rural Chinese adults
Li, Ruiying (author) / Chen, Gongbo (author) / Pan, Mingming (author) / Hou, Xiaoyu (author) / Kang, Ning (author) / Chen, Ruoling (author) / Yuchi, Yinghao (author) / Liao, Wei (author) / Liu, Xiaotian (author) / Mao, Zhenxing (author)
2022-08-30
Article (Journal)
Electronic Resource
English
Ozone , Residential greenness , Mitochondrial DNA copy number , Telomere length , Rural population , BMI , body mass index , CI , confidence interval , CV , coefficients of variation , IQR , interquartile range , mtDNA-CN , mitochondrial DNA copy number , NCDs , non-communicable diseases , NDVI , normalized difference vegetation index , T2DM , type 2 diabetes mellitus , TL , telomere length
Associations between residential greenness and blood lipids in Chinese Uyghur adults
| DOAJ | 2020