A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Prenatal exposure to polycyclic aromatic hydrocarbons and cognition in early childhood
https://orcid.org/0000-0001-9029-8178
https://orcid.org/0000-0003-1024-8184
https://orcid.org/0000-0001-6552-898X
https://orcid.org/0000-0003-2606-2050
https://orcid.org/0000-0001-9463-524X
https://orcid.org/0000-0002-8132-8045
https://orcid.org/0000-0002-1928-597X
Graphical abstract Display Omitted
Highlights This study examined associations of prenatal PAH exposure and child cognition. The sample was a large, socio-demographically diverse pooled multi-cohort sample. Prenatal PAHs were not associated with cognition in the overall sample. Early and pregnancy-averaged 2-NAP associated with lower cognition in a subsample. Our results using three measures of PAH exposure suggest inverse associations on IQ.
Abstract Background Epidemiological evidence for gestational polycyclic aromatic hydrocarbon (PAH) exposure and adverse child cognitive outcomes is mixed; little is known about critical windows of exposure. Objective We investigated associations between prenatal PAH exposure and child cognition in a large, multi-site study. Methods We included mother–child dyads from two pooled prospective pregnancy cohorts (CANDLE and TIDES, N = 1,223) in the ECHO-PATHWAYS Consortium. Seven urinary mono-hydroxylated PAH metabolites were measured in mid-pregnancy in both cohorts as well as early and late pregnancy in TIDES. Child intelligence quotient (IQ) was assessed between ages 4–6. Associations between individual PAH metabolites and IQ were estimated with multivariable linear regression. Interaction terms were used to examine effect modification by child sex and maternal obesity. We explored associations of PAH metabolite mixtures with IQ using weighted quantile sum regression. In TIDES, we averaged PAH metabolites over three periods of pregnancy and by pregnancy period to investigate associations between PAH metabolites and IQ. Results In the combined sample, PAH metabolites were not associated with IQ after full adjustment, nor did we observe associations with PAH mixtures. Tests of effect modification were null except for the association between 2-hydroxynaphthalene and IQ, which was negative in males (βmales = −0.67 [95%CI:−1.47,0.13]) and positive in females (βfemales = 0.31 [95%CI:−0.52,1.13])(pinteraction = 0.04). In analyses across pregnancy (TIDES-only), inverse associations with IQ were observed for 2-hydroxyphenanthrene averaged across pregnancy (β = −1.28 [95%CI:−2.53,−0.03]) and in early pregnancy (β = −1.14 [95%CI:−2.00,−0.28]). Significance In this multi-cohort analysis, we observed limited evidence of adverse associations of early pregnancy PAHs with child IQ. Analyses in the pooled cohorts were null. However, results also indicated that utilizing more than one exposure measures across pregnancy could improve the ability to detect associations by identifying sensitive windows and improving the reliability of exposure measurement. More research with multiple timepoints of PAH assessment is warranted.
Prenatal exposure to polycyclic aromatic hydrocarbons and cognition in early childhood
https://orcid.org/0000-0001-9029-8178
https://orcid.org/0000-0003-1024-8184
https://orcid.org/0000-0001-6552-898X
https://orcid.org/0000-0003-2606-2050
https://orcid.org/0000-0001-9463-524X
https://orcid.org/0000-0002-8132-8045
https://orcid.org/0000-0002-1928-597X
Graphical abstract Display Omitted
Highlights This study examined associations of prenatal PAH exposure and child cognition. The sample was a large, socio-demographically diverse pooled multi-cohort sample. Prenatal PAHs were not associated with cognition in the overall sample. Early and pregnancy-averaged 2-NAP associated with lower cognition in a subsample. Our results using three measures of PAH exposure suggest inverse associations on IQ.
Abstract Background Epidemiological evidence for gestational polycyclic aromatic hydrocarbon (PAH) exposure and adverse child cognitive outcomes is mixed; little is known about critical windows of exposure. Objective We investigated associations between prenatal PAH exposure and child cognition in a large, multi-site study. Methods We included mother–child dyads from two pooled prospective pregnancy cohorts (CANDLE and TIDES, N = 1,223) in the ECHO-PATHWAYS Consortium. Seven urinary mono-hydroxylated PAH metabolites were measured in mid-pregnancy in both cohorts as well as early and late pregnancy in TIDES. Child intelligence quotient (IQ) was assessed between ages 4–6. Associations between individual PAH metabolites and IQ were estimated with multivariable linear regression. Interaction terms were used to examine effect modification by child sex and maternal obesity. We explored associations of PAH metabolite mixtures with IQ using weighted quantile sum regression. In TIDES, we averaged PAH metabolites over three periods of pregnancy and by pregnancy period to investigate associations between PAH metabolites and IQ. Results In the combined sample, PAH metabolites were not associated with IQ after full adjustment, nor did we observe associations with PAH mixtures. Tests of effect modification were null except for the association between 2-hydroxynaphthalene and IQ, which was negative in males (βmales = −0.67 [95%CI:−1.47,0.13]) and positive in females (βfemales = 0.31 [95%CI:−0.52,1.13])(pinteraction = 0.04). In analyses across pregnancy (TIDES-only), inverse associations with IQ were observed for 2-hydroxyphenanthrene averaged across pregnancy (β = −1.28 [95%CI:−2.53,−0.03]) and in early pregnancy (β = −1.14 [95%CI:−2.00,−0.28]). Significance In this multi-cohort analysis, we observed limited evidence of adverse associations of early pregnancy PAHs with child IQ. Analyses in the pooled cohorts were null. However, results also indicated that utilizing more than one exposure measures across pregnancy could improve the ability to detect associations by identifying sensitive windows and improving the reliability of exposure measurement. More research with multiple timepoints of PAH assessment is warranted.
Prenatal exposure to polycyclic aromatic hydrocarbons and cognition in early childhood
https://orcid.org/0000-0001-9029-8178
https://orcid.org/0000-0003-1024-8184
https://orcid.org/0000-0001-6552-898X
https://orcid.org/0000-0003-2606-2050
https://orcid.org/0000-0001-9463-524X
https://orcid.org/0000-0002-8132-8045
https://orcid.org/0000-0002-1928-597X
Graphical abstract Display Omitted
Highlights This study examined associations of prenatal PAH exposure and child cognition. The sample was a large, socio-demographically diverse pooled multi-cohort sample. Prenatal PAHs were not associated with cognition in the overall sample. Early and pregnancy-averaged 2-NAP associated with lower cognition in a subsample. Our results using three measures of PAH exposure suggest inverse associations on IQ.
Abstract Background Epidemiological evidence for gestational polycyclic aromatic hydrocarbon (PAH) exposure and adverse child cognitive outcomes is mixed; little is known about critical windows of exposure. Objective We investigated associations between prenatal PAH exposure and child cognition in a large, multi-site study. Methods We included mother–child dyads from two pooled prospective pregnancy cohorts (CANDLE and TIDES, N = 1,223) in the ECHO-PATHWAYS Consortium. Seven urinary mono-hydroxylated PAH metabolites were measured in mid-pregnancy in both cohorts as well as early and late pregnancy in TIDES. Child intelligence quotient (IQ) was assessed between ages 4–6. Associations between individual PAH metabolites and IQ were estimated with multivariable linear regression. Interaction terms were used to examine effect modification by child sex and maternal obesity. We explored associations of PAH metabolite mixtures with IQ using weighted quantile sum regression. In TIDES, we averaged PAH metabolites over three periods of pregnancy and by pregnancy period to investigate associations between PAH metabolites and IQ. Results In the combined sample, PAH metabolites were not associated with IQ after full adjustment, nor did we observe associations with PAH mixtures. Tests of effect modification were null except for the association between 2-hydroxynaphthalene and IQ, which was negative in males (βmales = −0.67 [95%CI:−1.47,0.13]) and positive in females (βfemales = 0.31 [95%CI:−0.52,1.13])(pinteraction = 0.04). In analyses across pregnancy (TIDES-only), inverse associations with IQ were observed for 2-hydroxyphenanthrene averaged across pregnancy (β = −1.28 [95%CI:−2.53,−0.03]) and in early pregnancy (β = −1.14 [95%CI:−2.00,−0.28]). Significance In this multi-cohort analysis, we observed limited evidence of adverse associations of early pregnancy PAHs with child IQ. Analyses in the pooled cohorts were null. However, results also indicated that utilizing more than one exposure measures across pregnancy could improve the ability to detect associations by identifying sensitive windows and improving the reliability of exposure measurement. More research with multiple timepoints of PAH assessment is warranted.
Prenatal exposure to polycyclic aromatic hydrocarbons and cognition in early childhood
Sun, Bob (author) / Wallace, Erin R. (author) / Ni, Yu (author) / Loftus, Christine T. (author) / Szpiro, Adam (author) / Day, Drew (author) / Barrett, Emily S. (author) / Nguyen, Ruby H.N. (author) / Kannan, Kurunthachalam (author) / Robinson, Morgan (author)
2023-05-30
Article (Journal)
Electronic Resource
English
Polycyclic aromatic hydrocarbons , Neurodevelopment , Prenatal , 1nap , 1-hydroxynaphthalene , 2nap , 2-hydroxynaphthalene , 2phen , 2-hydroxyphenanthrene , 3phen , 3-hydroxyphenanthrene , 19-phen , 1/9-hydroxyphenanthrene , 239fluo , 2/3/9-hydroxyfluorene , 1pyr , 1-hydroxypyrene , nap sum , sum of hydroxynaphthalenes , phen sum , sum of hydroxyphenanthrenes , 95% CI , 95% Confidence Interval , BMI , Body mass index , CLMI , Censored Likelihood Multiple Imputation , LOD , Limit of Detection , IQ , Intellectual Quotient , OH-PAH , Hydroxy-Polycyclic Aromatic Hydrocarbon , PAH , Polycyclic Aromatic Hydrocarbon , WISC-V , Wechsler Intelligence Scale for Children Fifth Edition , WQS , Weighted Quantile Sum Regression
Prenatal exposure to polycyclic aromatic hydrocarbons and cognition in early childhood
| Elsevier | 2023
Prenatal exposure to polycyclic aromatic hydrocarbons and cognition in early childhood
| DOAJ | 2023
Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons
| Elsevier | 2023