A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Geospatial-temporal analysis of the impact of ozone on asthma rescue inhaler use
Highlights This study is one of the first to use an objective measure of short-acting beta-agonist (SABA) bronchodilator use to assess the association of short-term exposures to air pollution with asthma symptoms. We used a GPS-enabled small electronic medication monitor to track SABA use and assign air pollutant exposures based on the geocoordinates of the inhaler activation location. We found significant positive associations between 4-h ozone exposures and SABA inhaler use. The results of this study add to the body of evidence documenting an association between ozone exposure and asthma exacerbations.
Abstract Rationale Asthma is one of the most common chronic respiratory diseases in the United States. Several outdoor air pollutants have been associated with asthma morbidity. Previous studies of the effects of short-term air pollution exposure have been limited by potential exposure misclassification and limited spatial and temporal resolution of asthma outcome measures. Objectives We aimed to assess the association of short-term air pollutant exposure with the use of short-acting beta-2 agonists (SABA) for asthma by monitoring the time and place of occurrence with electronic medication monitors. Methods In a cohort of adults and children with asthma (n = 287; 60% female), we deployed electronic medication monitors fitted to metered-dose inhalers to monitor SABA use, capturing the date, time and location of use. We assigned pollutant exposures based on each actuation’s time and location (4-h mean measures for ozone and particulate matter of 2.5 µm or smaller (PM2.5)), assessed associations using generalized linear models and explored age-specific effects. Measurements and Main Results Ambient ozone exposure was positively associated with SABA use (p = 0.01). Age-specific associations were identified (interaction p = 0.01), with a larger increase in SABA use for children (11.3%; 95% CI: 7.0%–18.2%) than adults (8.4%; 95% CI: 6.4%–11.0%) per IQR increase of ozone (16.8 ppb). Conclusions These findings support existing evidence that short-term exposure to ozone can cause morbidity in individuals with asthma, and suggest that ozone exposures below the current U.S. EPA standard may be associated with increased SABA use.
Geospatial-temporal analysis of the impact of ozone on asthma rescue inhaler use
Highlights This study is one of the first to use an objective measure of short-acting beta-agonist (SABA) bronchodilator use to assess the association of short-term exposures to air pollution with asthma symptoms. We used a GPS-enabled small electronic medication monitor to track SABA use and assign air pollutant exposures based on the geocoordinates of the inhaler activation location. We found significant positive associations between 4-h ozone exposures and SABA inhaler use. The results of this study add to the body of evidence documenting an association between ozone exposure and asthma exacerbations.
Abstract Rationale Asthma is one of the most common chronic respiratory diseases in the United States. Several outdoor air pollutants have been associated with asthma morbidity. Previous studies of the effects of short-term air pollution exposure have been limited by potential exposure misclassification and limited spatial and temporal resolution of asthma outcome measures. Objectives We aimed to assess the association of short-term air pollutant exposure with the use of short-acting beta-2 agonists (SABA) for asthma by monitoring the time and place of occurrence with electronic medication monitors. Methods In a cohort of adults and children with asthma (n = 287; 60% female), we deployed electronic medication monitors fitted to metered-dose inhalers to monitor SABA use, capturing the date, time and location of use. We assigned pollutant exposures based on each actuation’s time and location (4-h mean measures for ozone and particulate matter of 2.5 µm or smaller (PM2.5)), assessed associations using generalized linear models and explored age-specific effects. Measurements and Main Results Ambient ozone exposure was positively associated with SABA use (p = 0.01). Age-specific associations were identified (interaction p = 0.01), with a larger increase in SABA use for children (11.3%; 95% CI: 7.0%–18.2%) than adults (8.4%; 95% CI: 6.4%–11.0%) per IQR increase of ozone (16.8 ppb). Conclusions These findings support existing evidence that short-term exposure to ozone can cause morbidity in individuals with asthma, and suggest that ozone exposures below the current U.S. EPA standard may be associated with increased SABA use.
Geospatial-temporal analysis of the impact of ozone on asthma rescue inhaler use
Pepper, Joshua R. (author) / Barrett, Meredith A. (author) / Su, Jason G. (author) / Merchant, Rajan (author) / Henderson, Kelly (author) / Van Sickle, David (author) / Balmes, John R. (author)
2019-11-12
Article (Journal)
Electronic Resource
English
Geospatial-temporal analysis of the impact of ozone on asthma rescue inhaler use
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