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Effect of a clean stove intervention on inflammatory biomarkers in pregnant women in Ibadan, Nigeria: A randomized controlled study
AbstractBackgroundExposure to household air pollution (HAP) has been linked to systemic inflammation. We determined the impact of transition from traditional firewood/kerosene stove to bioethanol-burning stove on inflammatory biomarkers in pregnant Nigerian women.MethodsWomen (n=324), cooking with kerosene/firewood, were recruited during their first trimester of pregnancy from June 2013–October 2015 and were randomly allocated to either control (n=162) or intervention (n=162) group using web-based randomization. Controls continued to use their own firewood/kerosene stove, while intervention participants received bioethanol CleanCook stoves. Serum concentrations of retinol-binding protein (RBP), malondialdehyde (MDA), tumor necrosis factor alpha (TNF)-α, interleukin (IL)-6, and IL-8 were measured by ELISA.ResultsAfter excluding 53 women (loss of follow-up, untimely biomarker assessments, incorrect dates of enrollment), data from 271 women were included in analysis. Mean (SD) change in RBP, MDA, TNF-α, IL-6, and IL-8 between baseline and third trimester was −2.16 (4.47), −19.6 (46.4), 3.72 (37.2), 0.51 (14.4), and 13.2 (197), respectively, in intervention and −2.25 (4.30), −24.6 (43.6), 7.17 (32.6), −1.79, (11.4), and 31.3 (296) in control groups. None of these changes differed significantly between the two treatment arms. However, changes from baseline in TNF-α levels were significantly different between intervention and control groups in subset of women (n=99) using firewood before trial (−7.03 [32.9] vs. +12.4 [33.6]; 95% CI for group difference: −35.4 to −3.4, p=0.018).ConclusionsDecrease in TNF-α concentration from baseline to third trimesters in intervention group women could indicate reduced cardiovascular stress and prothrombotic effects from decreased HAP. Our findings suggest that ethanol-burning stoves may mitigate cardiovascular health risks.
HighlightsExposure to household air pollution (HAP) has been linked to systemic inflammation.Determined impact of transition from traditional firewood/kerosene fuel to ethanol on inflammatory biomarkers in pregnant Nigerian women.Decrease in TNF-α from first to third trimesters in intervention group could indicate reduced cardiovascular stress and prothrombotic effects.Ethanol-burning stoves may mitigate cardiovascular health risks.Switching to ethanol-based stoves provides much-needed hope for a sustainable cooking alternative to unclean fuels in countries like Nigeria.This study has public and global health implication, supports and reiterates the need to follow WHO guidelines for indoor air quality.
Effect of a clean stove intervention on inflammatory biomarkers in pregnant women in Ibadan, Nigeria: A randomized controlled study
AbstractBackgroundExposure to household air pollution (HAP) has been linked to systemic inflammation. We determined the impact of transition from traditional firewood/kerosene stove to bioethanol-burning stove on inflammatory biomarkers in pregnant Nigerian women.MethodsWomen (n=324), cooking with kerosene/firewood, were recruited during their first trimester of pregnancy from June 2013–October 2015 and were randomly allocated to either control (n=162) or intervention (n=162) group using web-based randomization. Controls continued to use their own firewood/kerosene stove, while intervention participants received bioethanol CleanCook stoves. Serum concentrations of retinol-binding protein (RBP), malondialdehyde (MDA), tumor necrosis factor alpha (TNF)-α, interleukin (IL)-6, and IL-8 were measured by ELISA.ResultsAfter excluding 53 women (loss of follow-up, untimely biomarker assessments, incorrect dates of enrollment), data from 271 women were included in analysis. Mean (SD) change in RBP, MDA, TNF-α, IL-6, and IL-8 between baseline and third trimester was −2.16 (4.47), −19.6 (46.4), 3.72 (37.2), 0.51 (14.4), and 13.2 (197), respectively, in intervention and −2.25 (4.30), −24.6 (43.6), 7.17 (32.6), −1.79, (11.4), and 31.3 (296) in control groups. None of these changes differed significantly between the two treatment arms. However, changes from baseline in TNF-α levels were significantly different between intervention and control groups in subset of women (n=99) using firewood before trial (−7.03 [32.9] vs. +12.4 [33.6]; 95% CI for group difference: −35.4 to −3.4, p=0.018).ConclusionsDecrease in TNF-α concentration from baseline to third trimesters in intervention group women could indicate reduced cardiovascular stress and prothrombotic effects from decreased HAP. Our findings suggest that ethanol-burning stoves may mitigate cardiovascular health risks.
HighlightsExposure to household air pollution (HAP) has been linked to systemic inflammation.Determined impact of transition from traditional firewood/kerosene fuel to ethanol on inflammatory biomarkers in pregnant Nigerian women.Decrease in TNF-α from first to third trimesters in intervention group could indicate reduced cardiovascular stress and prothrombotic effects.Ethanol-burning stoves may mitigate cardiovascular health risks.Switching to ethanol-based stoves provides much-needed hope for a sustainable cooking alternative to unclean fuels in countries like Nigeria.This study has public and global health implication, supports and reiterates the need to follow WHO guidelines for indoor air quality.
Effect of a clean stove intervention on inflammatory biomarkers in pregnant women in Ibadan, Nigeria: A randomized controlled study
MD Olopade, Christopher O. (author) / Frank, Elizabeth (author) / Bartlett, Emily (author) / PhD Alexander, Donee (author) / PhD Dutta, Anindita (author) / MSc Ibigbami, Tope (author) / MSc Adu, Damilola (author) / MPH Olamijulo, John (author) / PhD Arinola, Ganiyu (author) / PhD Karrison, Theodore (author)
Environmental International ; 98 ; 181-190
2016-11-03
10 pages
Article (Journal)
Electronic Resource
English
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