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Fluorescent gold nanoclusters stabilized on halloysite nanotubes: in vitro study on cytotoxicity
Abstract Fluorescent gold nanoclusters (AuNCs) with an average diameter of 2.7 ± 1.0 nm stabilized with 11-mercaptoundecanoic acid were supported on halloysite nanotubes modified with aminosilane. The cytotoxicity of the obtained fluorescent material was investigated in A549 human cells. The AuNCs stabilized on halloysite showed good uptake by the cells. The material did not cause a pronounced toxic effect and visible membrane damage within the 25–50 μg/mL concentration range. An increase in nanocomposite concentration to 100 μg/mL led to massive cell death via apoptosis. This concentration-dependent toxicity mechanism allows for using AuNCs stabilized on halloysite for halloysite visualization in biological objects, bioimaging, and cancer therapy.
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Highlights Gold nanoclusters (AuNCs) were stabilized on the amino-modified halloysite (Hal). AuNCs/Hal demonstrated stable fluorescence and good uptake in А549 cells. AuNCs/Hal at 100 μg/mL concentration showed a pronounced toxic effect on А549 cells. AuNCs/Hal at the 25–50 μg/mL concentrations are suitable for bioimaging.
Fluorescent gold nanoclusters stabilized on halloysite nanotubes: in vitro study on cytotoxicity
Abstract Fluorescent gold nanoclusters (AuNCs) with an average diameter of 2.7 ± 1.0 nm stabilized with 11-mercaptoundecanoic acid were supported on halloysite nanotubes modified with aminosilane. The cytotoxicity of the obtained fluorescent material was investigated in A549 human cells. The AuNCs stabilized on halloysite showed good uptake by the cells. The material did not cause a pronounced toxic effect and visible membrane damage within the 25–50 μg/mL concentration range. An increase in nanocomposite concentration to 100 μg/mL led to massive cell death via apoptosis. This concentration-dependent toxicity mechanism allows for using AuNCs stabilized on halloysite for halloysite visualization in biological objects, bioimaging, and cancer therapy.
Graphical abstract Display Omitted
Highlights Gold nanoclusters (AuNCs) were stabilized on the amino-modified halloysite (Hal). AuNCs/Hal demonstrated stable fluorescence and good uptake in А549 cells. AuNCs/Hal at 100 μg/mL concentration showed a pronounced toxic effect on А549 cells. AuNCs/Hal at the 25–50 μg/mL concentrations are suitable for bioimaging.
Fluorescent gold nanoclusters stabilized on halloysite nanotubes: in vitro study on cytotoxicity
Gorbachevskii, Maksim V. (author) / Stavitskaya, Anna V. (author) / Novikov, Andrei A. (author) / Fakhrullin, Rawil F. (author) / Rozhina, Elvira V. (author) / Naumenko, Ekaterina A. (author) / Vinokurov, Vladimir A. (author)
Applied Clay Science ; 207
2021-04-19
Article (Journal)
Electronic Resource
English
Halloysite clay nanotubes hold promise
| British Library Online Contents | 2016
Halloysite clay nanotubes hold promise
| British Library Online Contents | 2016