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Prenatal exposure to organochlorine compounds and neuropsychological development up to two years of life
Abstract Polychlorinated biphenyls (PCB), hexachlorobenzene (HCB), and dichlorodiphenyl dichloroethylene (pp′DDE) are persistent, bioaccumulative, and toxic environmental pollutants with potential neurotoxic effects. Despite a growing body of studies investigating the health effects associated with these compounds, their specific effects on early neuropsychological development remain unclear. We investigated such neuropsychological effects in a population-based birth cohort based in three regions in Spain (Sabadell, Gipuzkoa, and Valencia) derived from the INMA [Environment and Childhood] Project. The main analyses in this report were based on 1391 mother–child pairs with complete information on maternal levels of organochlorine compounds and child neuropsychological assessment (Bayley Scales of Infant Development) at age 14months. We found that prenatal PCB exposure, particularly to congeners 138 and 153, resulted in impairment of psychomotor development (coefficient=−1.24, 95% confidence interval=−2.41, −0.07), but found no evidence for effects on cognitive development. Prenatal exposure to pp′DDE or HCB was not associated with early neuropsychological development. The negative effects of exposure to PCBs on early psychomotor development suggest that the potential neurotoxic effects of these compounds may be evident even at low doses.
Highlights ► Neuropsychological development at the age of 14months was assessed using Bayley Scales of Infant Development. ► Prenatal exposure to low levels of PCBs was related with a delay in the early psychomotor development. ► Neither DDE nor HCB were associated with the early neuropsychological development.
Prenatal exposure to organochlorine compounds and neuropsychological development up to two years of life
Abstract Polychlorinated biphenyls (PCB), hexachlorobenzene (HCB), and dichlorodiphenyl dichloroethylene (pp′DDE) are persistent, bioaccumulative, and toxic environmental pollutants with potential neurotoxic effects. Despite a growing body of studies investigating the health effects associated with these compounds, their specific effects on early neuropsychological development remain unclear. We investigated such neuropsychological effects in a population-based birth cohort based in three regions in Spain (Sabadell, Gipuzkoa, and Valencia) derived from the INMA [Environment and Childhood] Project. The main analyses in this report were based on 1391 mother–child pairs with complete information on maternal levels of organochlorine compounds and child neuropsychological assessment (Bayley Scales of Infant Development) at age 14months. We found that prenatal PCB exposure, particularly to congeners 138 and 153, resulted in impairment of psychomotor development (coefficient=−1.24, 95% confidence interval=−2.41, −0.07), but found no evidence for effects on cognitive development. Prenatal exposure to pp′DDE or HCB was not associated with early neuropsychological development. The negative effects of exposure to PCBs on early psychomotor development suggest that the potential neurotoxic effects of these compounds may be evident even at low doses.
Highlights ► Neuropsychological development at the age of 14months was assessed using Bayley Scales of Infant Development. ► Prenatal exposure to low levels of PCBs was related with a delay in the early psychomotor development. ► Neither DDE nor HCB were associated with the early neuropsychological development.
Prenatal exposure to organochlorine compounds and neuropsychological development up to two years of life
Forns, Joan (author) / Lertxundi, Nerea (author) / Aranbarri, Aritz (author) / Murcia, Mario (author) / Gascon, Mireia (author) / Martinez, David (author) / Grellier, James (author) / Lertxundi, Aitana (author) / Julvez, Jordi (author) / Fano, Eduardo (author)
Environmental International ; 45 ; 72-77
2012-04-14
6 pages
Article (Journal)
Electronic Resource
English
(PCB) , Polychlorinated biphenyls , (HCB) , Hexachlorobenzene , (pp′DDT) , dichlorodiphenyltrichloroethane , (pp′DDE) , dichlorodiphenyl dichloroethylene , INMA , [Environment and Childhood] Project , (OCs) , Organochlorine Compounds , (Coef) , Coefficient , (BSID) , Bayley Scales of Infant Development , (GC-ECD) , gas chromatography with electron capture detector , (GC-MSD) , gas chromatography coupled to a mass spectrometer detector , (LOD) , limits of detection , (LOQ) , limits of quantification , Child development , Organochlorine compounds , Dichlorodiphenyl dichloroethylene , Neuropsychology
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