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Biomonitoring of exposure to potentially genotoxic substances from environmental tobacco smoke
AbstractIn two experimental studies, 10 volunteer nonsmokers were put on a controlled diet and exposed to two different ETS concentrations for 8 hours. During exposure in Experiment 1, the average indoor air levels of CO, NO, NO2, formaldehyde, and nicotine reached 10 μL/L, 160 nL/L, 20 nL/L, 40 μg/m3 and 60 μg/m3, respectively. During Experiment 2, the respective concentrations were 20 to 25 μL/L, 310 nL/L, 150 nL/L, 50 μg/m3 and 120 μg/m3. On the average, carboxyhemoglobin increased by 0.7% after exposure in Experiment 1 and by 2.0% in Experiment 2. The serum continine concentration increased by 1 ng/mL and 5 ng/mL in Experiment 1 and 2, respectively. On the average, the subjects excreted 24 μg (Experiment 1) and 70 μg cotinine (Experiment 2) in the 24-h urine after ETS exposure. No statistically significant increase was found in the urinary mutagenicity after either of the two exposure regimens, whereas thioether excretion was significantly elevated. The data suggest that nonsmokers in real-life situations take up very low doses of ETS constituents, and detoxification of the genotoxic substances inhaled is effective.
Biomonitoring of exposure to potentially genotoxic substances from environmental tobacco smoke
AbstractIn two experimental studies, 10 volunteer nonsmokers were put on a controlled diet and exposed to two different ETS concentrations for 8 hours. During exposure in Experiment 1, the average indoor air levels of CO, NO, NO2, formaldehyde, and nicotine reached 10 μL/L, 160 nL/L, 20 nL/L, 40 μg/m3 and 60 μg/m3, respectively. During Experiment 2, the respective concentrations were 20 to 25 μL/L, 310 nL/L, 150 nL/L, 50 μg/m3 and 120 μg/m3. On the average, carboxyhemoglobin increased by 0.7% after exposure in Experiment 1 and by 2.0% in Experiment 2. The serum continine concentration increased by 1 ng/mL and 5 ng/mL in Experiment 1 and 2, respectively. On the average, the subjects excreted 24 μg (Experiment 1) and 70 μg cotinine (Experiment 2) in the 24-h urine after ETS exposure. No statistically significant increase was found in the urinary mutagenicity after either of the two exposure regimens, whereas thioether excretion was significantly elevated. The data suggest that nonsmokers in real-life situations take up very low doses of ETS constituents, and detoxification of the genotoxic substances inhaled is effective.
Biomonitoring of exposure to potentially genotoxic substances from environmental tobacco smoke
Scherer, Gerhard (author) / Westphal, Kord (author) / Adlkofer, Franz (author) / Sorsa, Marja (author)
Environmental International ; 15 ; 49-56
1987-05-05
8 pages
Article (Journal)
Electronic Resource
English
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