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The invisible Threat: Assessing the reproductive and transgenerational impacts of micro- and nanoplastics on fish
https://orcid.org/0000-0001-7747-9951
Graphical abstract Display Omitted
Highlights MNPs affect fish reproduction under isolated and combined pollution exposures. The risk of MNPs causing heritable toxic effects in fish offspring is highlighted. Gonadal damage and hormonal disruption are two biological pathways affected by MNPs. Points out research gaps in understanding MNPs' size-specific and long-term effects. Assessing MNP ecological risks is crucial to protecting aquatic life.
Abstract Micro- and nanoplastics (MNPs), emerging as pervasive environmental pollutants, present multifaceted threats to diverse ecosystems. This review critically examines the ability of MNPs to traverse biological barriers in fish, leading to their accumulation in gonadal tissues and subsequent reproductive toxicity. A focal concern is the potential transgenerational harm, where offspring not directly exposed to MNPs exhibit toxic effects. Characterized by extensive specific surface areas and marked surface hydrophobicity, MNPs readily adsorb and concentrate other environmental contaminants, potentially intensifying reproductive and transgenerational toxicity. This comprehensive analysis aims to provide profound insights into the repercussions of MNPs on fish reproductive health and progeny, highlighting the intricate interplay between MNPs and other pollutants. We delve into the mechanisms of MNPs-induced reproductive toxicity, including gonadal histopathologic alterations, oxidative stress, and disruptions in the hypothalamic-pituitary–gonadal axis. The review also underscores the urgency for future research to explore the size-specific toxic dynamics of MNPs and the long-term implications of chronic exposure. Understanding these aspects is crucial for assessing the ecological risks posed by MNPs and formulating strategies to safeguard aquatic life.
The invisible Threat: Assessing the reproductive and transgenerational impacts of micro- and nanoplastics on fish
https://orcid.org/0000-0001-7747-9951
Graphical abstract Display Omitted
Highlights MNPs affect fish reproduction under isolated and combined pollution exposures. The risk of MNPs causing heritable toxic effects in fish offspring is highlighted. Gonadal damage and hormonal disruption are two biological pathways affected by MNPs. Points out research gaps in understanding MNPs' size-specific and long-term effects. Assessing MNP ecological risks is crucial to protecting aquatic life.
Abstract Micro- and nanoplastics (MNPs), emerging as pervasive environmental pollutants, present multifaceted threats to diverse ecosystems. This review critically examines the ability of MNPs to traverse biological barriers in fish, leading to their accumulation in gonadal tissues and subsequent reproductive toxicity. A focal concern is the potential transgenerational harm, where offspring not directly exposed to MNPs exhibit toxic effects. Characterized by extensive specific surface areas and marked surface hydrophobicity, MNPs readily adsorb and concentrate other environmental contaminants, potentially intensifying reproductive and transgenerational toxicity. This comprehensive analysis aims to provide profound insights into the repercussions of MNPs on fish reproductive health and progeny, highlighting the intricate interplay between MNPs and other pollutants. We delve into the mechanisms of MNPs-induced reproductive toxicity, including gonadal histopathologic alterations, oxidative stress, and disruptions in the hypothalamic-pituitary–gonadal axis. The review also underscores the urgency for future research to explore the size-specific toxic dynamics of MNPs and the long-term implications of chronic exposure. Understanding these aspects is crucial for assessing the ecological risks posed by MNPs and formulating strategies to safeguard aquatic life.
The invisible Threat: Assessing the reproductive and transgenerational impacts of micro- and nanoplastics on fish
https://orcid.org/0000-0001-7747-9951
Graphical abstract Display Omitted
Highlights MNPs affect fish reproduction under isolated and combined pollution exposures. The risk of MNPs causing heritable toxic effects in fish offspring is highlighted. Gonadal damage and hormonal disruption are two biological pathways affected by MNPs. Points out research gaps in understanding MNPs' size-specific and long-term effects. Assessing MNP ecological risks is crucial to protecting aquatic life.
Abstract Micro- and nanoplastics (MNPs), emerging as pervasive environmental pollutants, present multifaceted threats to diverse ecosystems. This review critically examines the ability of MNPs to traverse biological barriers in fish, leading to their accumulation in gonadal tissues and subsequent reproductive toxicity. A focal concern is the potential transgenerational harm, where offspring not directly exposed to MNPs exhibit toxic effects. Characterized by extensive specific surface areas and marked surface hydrophobicity, MNPs readily adsorb and concentrate other environmental contaminants, potentially intensifying reproductive and transgenerational toxicity. This comprehensive analysis aims to provide profound insights into the repercussions of MNPs on fish reproductive health and progeny, highlighting the intricate interplay between MNPs and other pollutants. We delve into the mechanisms of MNPs-induced reproductive toxicity, including gonadal histopathologic alterations, oxidative stress, and disruptions in the hypothalamic-pituitary–gonadal axis. The review also underscores the urgency for future research to explore the size-specific toxic dynamics of MNPs and the long-term implications of chronic exposure. Understanding these aspects is crucial for assessing the ecological risks posed by MNPs and formulating strategies to safeguard aquatic life.
The invisible Threat: Assessing the reproductive and transgenerational impacts of micro- and nanoplastics on fish
Yi, Jia (author) / Ma, Yilei (author) / Ruan, Jing (author) / You, Si (author) / Ma, Jiahui (author) / Yu, Haiyang (author) / Zhao, Jing (author) / Zhang, Kun (author) / Yang, Qinsi (author) / Jin, Libo (author)
2024-01-05
Article (Journal)
Electronic Resource
English
Microplastics , Nanoplastics , Reproductive toxicity , Transgenerational effects , Parental transfer , AR , Androgen receptor , BaP , Benzo[a]pyrene , BP3 , Benzophenone-3 , CAT , Catalase , CHG , Choriopoietin , CNS , Central nervous system , DES , Diethylstilbestrol , E2 , Estradiol , EHS , Ethylhexyl salicylate , ER , Estrogen receptors , FSHβ , Follicle-stimulating hormone β , FSHR , Follicle-stimulating hormone receptor , GPX , Glutathione peroxidase , GH/IGF-I , Growth hormone/insulin-like growth factor-I , GnRHR , Gonadotropin-releasing hormone receptor , GSH , Glutathione , GST , Glutathione S-transferase , GTHα , Gonadotropin-α , HPG , Hypothalamic-pituitary−gonadal , HPT , Hypothalamus-pituitary-thyroid , LHβ , Luteinizing hormone β , LHR , Luteinizing hormone receptor , MC-LR , Microcystin-LR , MDA , Malondialdehyde , MNPs , Micro- and nanoplastics , MPs , mGnRH , Gonadotropin-releasing hormone , NPs , PFOS , Perfluorooctanesulfonic acid , Phe , Phenanthroline , PS MPs , Polystyrene microplastics , PVC , Polyvinyl chloride , ROS , Reactive oxygen species , SOD , Superoxide dismutase , StAR , Steroidogenic acute regulatory protein , T , Testosterone , T3 , 3,5,3′-triiodothyronine , T4 , Thyroxine , TDCIPP , Tris(1,3-dichloro-2propyl) phosphate , TPhP , Triphenyl phosphate , VTG , Vitellogenin , 3βHSD , 3β-Hydroxysteroid dehydrogenase , 11βHSD , 11β-hydroxysteroid dehydrogenase , 17βHSD , 17β-hydroxysteroid dehydrogenase , 20βHSD , 20β-hydroxysteroid dehydrogenase
| Elsevier | 2024
Reproductive toxicity of micro- and nanoplastics
| Elsevier | 2023
| Online Contents | 2016