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A novel insoluble film based on crosslinked-starch with gelatin containing ZnO-loaded halloysite nanotube and bacterial nanocellulose for wound healing applications
Abstract The Fabrication of appropriate skin wound dressing is a promising strategy to treat patients with severe skin injuries. In recent years, significant effort is invested in nanocomposite films made from natural polymers that have a lot of potential as artificial scaffolds for wound healing. Thus, the aim of this research was to produce nanocomposite film based on dialdehyde-corn starch/gelatin/bacterial nano-cellulose containing ZnO-loaded halloysite nanotubes (DAS-G/BC/ZHal) for tissue engineering applications. The synthesized films were examined for thermal stability, swelling ratio, degradation, and mechanical properties. The results revealed that by increasing the amount of BC (from 0.03 wt% to 0.12 wt%) in the films; the thermal stability improved. Also, the synthesized ZHal were incorporated into the DAS-G/BC nanocomposite films as a reinforcing filler and a good antibacterial agent with different concentrations of ZHal (3 and 5 wt%). Moreover, the produced DAS-G/BC/ZHal nanocomposite films significantly (P < 0.05) improved cell growth of NIH-3 T3 fibroblast cells and proliferation (around 150%) in the presence of BC and ZHal which revealed that these nanocomposite films are cytocompatible. The antibacterial activity was evaluated against Escherichia coli (E.Coli), and Staphylococcus aureus (S.aureus), which are the pathogens bacteria detected in wound infections. According to the obtained results, the generated films showed a suitable biomedical scaffold with excellent performance in tissue engineering applications.
Highlights ZnO-loaded halloysite nanotubes (ZHNTs) was successfully prepared. A film based on dialdehyde-starch/gelatin/bacterial nano-cellulose was developed. Bacterial nano-cellulose (BC) improved the thermal stability of the films. The cell growth was improved by the film containing of BC and ZHNTs. The optimal films showed the antibacterial activity against pathogens bacteria.
A novel insoluble film based on crosslinked-starch with gelatin containing ZnO-loaded halloysite nanotube and bacterial nanocellulose for wound healing applications
Abstract The Fabrication of appropriate skin wound dressing is a promising strategy to treat patients with severe skin injuries. In recent years, significant effort is invested in nanocomposite films made from natural polymers that have a lot of potential as artificial scaffolds for wound healing. Thus, the aim of this research was to produce nanocomposite film based on dialdehyde-corn starch/gelatin/bacterial nano-cellulose containing ZnO-loaded halloysite nanotubes (DAS-G/BC/ZHal) for tissue engineering applications. The synthesized films were examined for thermal stability, swelling ratio, degradation, and mechanical properties. The results revealed that by increasing the amount of BC (from 0.03 wt% to 0.12 wt%) in the films; the thermal stability improved. Also, the synthesized ZHal were incorporated into the DAS-G/BC nanocomposite films as a reinforcing filler and a good antibacterial agent with different concentrations of ZHal (3 and 5 wt%). Moreover, the produced DAS-G/BC/ZHal nanocomposite films significantly (P < 0.05) improved cell growth of NIH-3 T3 fibroblast cells and proliferation (around 150%) in the presence of BC and ZHal which revealed that these nanocomposite films are cytocompatible. The antibacterial activity was evaluated against Escherichia coli (E.Coli), and Staphylococcus aureus (S.aureus), which are the pathogens bacteria detected in wound infections. According to the obtained results, the generated films showed a suitable biomedical scaffold with excellent performance in tissue engineering applications.
Highlights ZnO-loaded halloysite nanotubes (ZHNTs) was successfully prepared. A film based on dialdehyde-starch/gelatin/bacterial nano-cellulose was developed. Bacterial nano-cellulose (BC) improved the thermal stability of the films. The cell growth was improved by the film containing of BC and ZHNTs. The optimal films showed the antibacterial activity against pathogens bacteria.
A novel insoluble film based on crosslinked-starch with gelatin containing ZnO-loaded halloysite nanotube and bacterial nanocellulose for wound healing applications
Jaberifard, Farnaz (author) / Ghorbani, Marjan (author) / Arsalani, Nasser (author) / Mostafavi, Hossein (author)
Applied Clay Science ; 230
2022-08-08
Article (Journal)
Electronic Resource
English
| British Library Online Contents | 2013