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Dose response to cancerogenic and mutagenic treatments
Abstract Thirty-seven dose-response curves involving animal and plant material, subjected to treatment with cancerogenic chemicals and low-energy transfer ionizing radiation, have been gathered from the literature. In addition, one experiment in which a nutritional factor was used has been included in the results. Our calculations indicate that all the responses appear to fit the equation f = (D n)/(K n + D n) where f is the fraction of subjects affected, D is the dose applied, and K is a constant characteristic of the cancerogen or treatment. Both of these parameters are raised to the nth power and result in a family of curves. The values of n were found to range between 0.33 and 3.13 with a value close to 1.00 (linear at low doses) in only three cases. Data from these 38 reports are displayed in a logarithmic plot on a single graph. In addition to the values of n and K, as well as the dosages and responses needed to construct this graph, are presented in two tables. Our mathematical treatment of the published data shows an unexpected universality of biological behavior that may be helpful in the extrapolation of experimental data to humans.
Dose response to cancerogenic and mutagenic treatments
Abstract Thirty-seven dose-response curves involving animal and plant material, subjected to treatment with cancerogenic chemicals and low-energy transfer ionizing radiation, have been gathered from the literature. In addition, one experiment in which a nutritional factor was used has been included in the results. Our calculations indicate that all the responses appear to fit the equation f = (D n)/(K n + D n) where f is the fraction of subjects affected, D is the dose applied, and K is a constant characteristic of the cancerogen or treatment. Both of these parameters are raised to the nth power and result in a family of curves. The values of n were found to range between 0.33 and 3.13 with a value close to 1.00 (linear at low doses) in only three cases. Data from these 38 reports are displayed in a logarithmic plot on a single graph. In addition to the values of n and K, as well as the dosages and responses needed to construct this graph, are presented in two tables. Our mathematical treatment of the published data shows an unexpected universality of biological behavior that may be helpful in the extrapolation of experimental data to humans.
Dose response to cancerogenic and mutagenic treatments
Totter, J.R. (author) / Finamore, F.J. (author)
Environmental International ; 1 ; 233-244
1978-07-27
12 pages
Article (Journal)
Electronic Resource
English
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