A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy
Highlights Air pollution during pregnancy associated with telomere length (TL) in newborns. Second trimester air pollution positively associated with umbilical cord blood TL. Third trimester air pollution inversely associated with umbilical cord blood TL. Air pollution at home and work show similar association with umbilical cord blood TL. No association between air pollution and TL in placenta or maternal blood.
Abstract Telomere length (TL) is a biomarker of biological aging that may be affected by prenatal exposure to air pollution. The aim of this study was to assess the association between prenatal exposure to air pollution and TL in maternal blood cells (leukocytes), placenta and umbilical cord blood cells, sampled immediately after birth in 296 Danish mother-child pairs from a birth cohort. Exposure data was obtained using the high-resolution and spatial–temporal air pollution modeling system DEHM-UBM-AirGIS for PM2.5, PM10, SO2, NH4 +, black carbon (BC), organic carbon (OC), CO, O3, NO2, and NOx at residential and occupational addresses of the participating women for the full duration of the pregnancy. The association between prenatal exposure to air pollutants and TL was investigated using distributed lag models. There were significant and positive associations between TL in umbilical cord blood cells and prenatal exposure to BC, OC, NO2, NOx, CO, and O3 during the second trimester. TL in umbilical cord blood was significantly and inversely associated with prenatal exposure to PM2.5, BC, OC, SO2, NH4 +, CO and NO2 during the third trimester. There were similar inverse associations between TL from umbilical cord blood cells and air pollution exposure at the residential and occupational addresses. There were weaker or no associations between air pollution exposure and TL in placenta tissue and maternal blood cells. In conclusion, both the second and third trimesters of pregnancy are shown to be sensitive windows of exposure to air pollution affecting fetal TL.
Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy
Highlights Air pollution during pregnancy associated with telomere length (TL) in newborns. Second trimester air pollution positively associated with umbilical cord blood TL. Third trimester air pollution inversely associated with umbilical cord blood TL. Air pollution at home and work show similar association with umbilical cord blood TL. No association between air pollution and TL in placenta or maternal blood.
Abstract Telomere length (TL) is a biomarker of biological aging that may be affected by prenatal exposure to air pollution. The aim of this study was to assess the association between prenatal exposure to air pollution and TL in maternal blood cells (leukocytes), placenta and umbilical cord blood cells, sampled immediately after birth in 296 Danish mother-child pairs from a birth cohort. Exposure data was obtained using the high-resolution and spatial–temporal air pollution modeling system DEHM-UBM-AirGIS for PM2.5, PM10, SO2, NH4 +, black carbon (BC), organic carbon (OC), CO, O3, NO2, and NOx at residential and occupational addresses of the participating women for the full duration of the pregnancy. The association between prenatal exposure to air pollutants and TL was investigated using distributed lag models. There were significant and positive associations between TL in umbilical cord blood cells and prenatal exposure to BC, OC, NO2, NOx, CO, and O3 during the second trimester. TL in umbilical cord blood was significantly and inversely associated with prenatal exposure to PM2.5, BC, OC, SO2, NH4 +, CO and NO2 during the third trimester. There were similar inverse associations between TL from umbilical cord blood cells and air pollution exposure at the residential and occupational addresses. There were weaker or no associations between air pollution exposure and TL in placenta tissue and maternal blood cells. In conclusion, both the second and third trimesters of pregnancy are shown to be sensitive windows of exposure to air pollution affecting fetal TL.
Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy
Harnung Scholten, Rebecca (author) / Møller, Peter (author) / Jovanovic Andersen, Zorana (author) / Dehlendorff, Christian (author) / Khan, Jibran (author) / Brandt, Jørgen (author) / Ketzel, Matthias (author) / Knudsen, Lisbeth E. (author) / Mathiesen, Line (author)
2020-10-08
Article (Journal)
Electronic Resource
English
Air pollution exposure , Leukocyte telomere length , <italic>In utero</italic> life , Biological aging , Prenatal exposure , Life expectancy , BC , black carbon , DEHM , Danish Eulerian Hemispheric Model , OC , organic carbon , OSPM , Operational Street Pollution Model , PM , particulate matter , TL , telomere length , T/S , fold difference in relative TL compared to the length of a single copy gene , UBM , Urban Background Model
| DOAJ | 2021
Effects of maternal exposure to ambient air pollution on newborn telomere length
| Elsevier | 2019
Effects of maternal exposure to ambient air pollution on newborn telomere length
| DOAJ | 2019
Long-term ozone exposure is positively associated with telomere length in critically ill patients
| DOAJ | 2020