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Serum per- and polyfluoroalkyl substances and abnormal lipid metabolism: A nationally representative cross-sectional study
https://orcid.org/0000-0002-7071-571X
Highlights Legacy and emerging (6:2Cl-PFESA) PFASs were positive associated with abnormal lipid metabolism. Lipid levels tended to be stable when PFOS and PFOA > 20 ng/mL, as well as 6:2Cl-PFESA level > 10 ng/mL. China's unique legacy PFAS substitutes (6:2Cl-PFESA) contributed less to lipid profiles than legacy PFAS. PFAS was more likely to have adverse effects on lipid profiles in diabetes patients.
Abstract Background The associations of legacy per- and polyfluoroalkyl substances (PFAS) with lipid metabolism are controversial, and there is little information about the impact of emerging PFAS (6:2 Cl-PFESA) on lipid metabolism in China. Objectives We aimed to explore the associations of legacy and emerging PFAS with lipid profiles and dyslipidemia in Chinese adults. Methods We included 10,855 Chinese participants aged 18 years and above in the China National Human Biomonitoring. The associations of 8 PFAS with 5 lipid profiles and 4 dyslipidemia were investigated using weighted multiple linear regression or weighted logistic regression, and the dose–response associations were investigated using restricted cubic spline model. Results Among the 8 PFAS, the concentration of PFOS was the highest, with a geometric mean of 5.15 ng/mL, followed by PFOA and 6:2 Cl-PFESA, which were 4.26 and 1.63 ng/mL, respectively. Legacy (PFOA, PFOS, PFUnDA) or emerging (6:2 Cl-PFESA) PFAS were associated with lipid profiles (TC, LDL-C, HDL-C, non HDL-C) and dyslipidemia (high LDL-C, high TC, low HDL-C), and their effects on TC were most obvious. TC concentration increased by 0.595 mmol/L in the highest quartile (Q4) of PFOS when compared with the lowest quartile (Q1), (95 % CI:0.396, 0.794). Restricted cubic spline models showed that PFAS are nonlinearly associated with TC, non HDL-C, LDL-C and HDL-C, and that the lipid concentrations tend to be stable when PFOS and PFOA were > 20 ng/mL well as when the 6:2 Cl-PFESA level was > 10 ng/mL. The positive associations between PFAS mixtures and lipid profiles were also significant. Conclusions Single and mixed exposure to PFAS were positively associated with lipid profiles, and China's unique legacy PFAS substitutes (6:2 Cl-PFESA) contributed less to lipid profiles than legacy PFAS. In the future, cohort studies will be needed to confirm our findings.
Serum per- and polyfluoroalkyl substances and abnormal lipid metabolism: A nationally representative cross-sectional study
https://orcid.org/0000-0002-7071-571X
Highlights Legacy and emerging (6:2Cl-PFESA) PFASs were positive associated with abnormal lipid metabolism. Lipid levels tended to be stable when PFOS and PFOA > 20 ng/mL, as well as 6:2Cl-PFESA level > 10 ng/mL. China's unique legacy PFAS substitutes (6:2Cl-PFESA) contributed less to lipid profiles than legacy PFAS. PFAS was more likely to have adverse effects on lipid profiles in diabetes patients.
Abstract Background The associations of legacy per- and polyfluoroalkyl substances (PFAS) with lipid metabolism are controversial, and there is little information about the impact of emerging PFAS (6:2 Cl-PFESA) on lipid metabolism in China. Objectives We aimed to explore the associations of legacy and emerging PFAS with lipid profiles and dyslipidemia in Chinese adults. Methods We included 10,855 Chinese participants aged 18 years and above in the China National Human Biomonitoring. The associations of 8 PFAS with 5 lipid profiles and 4 dyslipidemia were investigated using weighted multiple linear regression or weighted logistic regression, and the dose–response associations were investigated using restricted cubic spline model. Results Among the 8 PFAS, the concentration of PFOS was the highest, with a geometric mean of 5.15 ng/mL, followed by PFOA and 6:2 Cl-PFESA, which were 4.26 and 1.63 ng/mL, respectively. Legacy (PFOA, PFOS, PFUnDA) or emerging (6:2 Cl-PFESA) PFAS were associated with lipid profiles (TC, LDL-C, HDL-C, non HDL-C) and dyslipidemia (high LDL-C, high TC, low HDL-C), and their effects on TC were most obvious. TC concentration increased by 0.595 mmol/L in the highest quartile (Q4) of PFOS when compared with the lowest quartile (Q1), (95 % CI:0.396, 0.794). Restricted cubic spline models showed that PFAS are nonlinearly associated with TC, non HDL-C, LDL-C and HDL-C, and that the lipid concentrations tend to be stable when PFOS and PFOA were > 20 ng/mL well as when the 6:2 Cl-PFESA level was > 10 ng/mL. The positive associations between PFAS mixtures and lipid profiles were also significant. Conclusions Single and mixed exposure to PFAS were positively associated with lipid profiles, and China's unique legacy PFAS substitutes (6:2 Cl-PFESA) contributed less to lipid profiles than legacy PFAS. In the future, cohort studies will be needed to confirm our findings.
Serum per- and polyfluoroalkyl substances and abnormal lipid metabolism: A nationally representative cross-sectional study
https://orcid.org/0000-0002-7071-571X
Highlights Legacy and emerging (6:2Cl-PFESA) PFASs were positive associated with abnormal lipid metabolism. Lipid levels tended to be stable when PFOS and PFOA > 20 ng/mL, as well as 6:2Cl-PFESA level > 10 ng/mL. China's unique legacy PFAS substitutes (6:2Cl-PFESA) contributed less to lipid profiles than legacy PFAS. PFAS was more likely to have adverse effects on lipid profiles in diabetes patients.
Abstract Background The associations of legacy per- and polyfluoroalkyl substances (PFAS) with lipid metabolism are controversial, and there is little information about the impact of emerging PFAS (6:2 Cl-PFESA) on lipid metabolism in China. Objectives We aimed to explore the associations of legacy and emerging PFAS with lipid profiles and dyslipidemia in Chinese adults. Methods We included 10,855 Chinese participants aged 18 years and above in the China National Human Biomonitoring. The associations of 8 PFAS with 5 lipid profiles and 4 dyslipidemia were investigated using weighted multiple linear regression or weighted logistic regression, and the dose–response associations were investigated using restricted cubic spline model. Results Among the 8 PFAS, the concentration of PFOS was the highest, with a geometric mean of 5.15 ng/mL, followed by PFOA and 6:2 Cl-PFESA, which were 4.26 and 1.63 ng/mL, respectively. Legacy (PFOA, PFOS, PFUnDA) or emerging (6:2 Cl-PFESA) PFAS were associated with lipid profiles (TC, LDL-C, HDL-C, non HDL-C) and dyslipidemia (high LDL-C, high TC, low HDL-C), and their effects on TC were most obvious. TC concentration increased by 0.595 mmol/L in the highest quartile (Q4) of PFOS when compared with the lowest quartile (Q1), (95 % CI:0.396, 0.794). Restricted cubic spline models showed that PFAS are nonlinearly associated with TC, non HDL-C, LDL-C and HDL-C, and that the lipid concentrations tend to be stable when PFOS and PFOA were > 20 ng/mL well as when the 6:2 Cl-PFESA level was > 10 ng/mL. The positive associations between PFAS mixtures and lipid profiles were also significant. Conclusions Single and mixed exposure to PFAS were positively associated with lipid profiles, and China's unique legacy PFAS substitutes (6:2 Cl-PFESA) contributed less to lipid profiles than legacy PFAS. In the future, cohort studies will be needed to confirm our findings.
Serum per- and polyfluoroalkyl substances and abnormal lipid metabolism: A nationally representative cross-sectional study
Wu, Bing (author) / Pan, Yitao (author) / Li, Zheng (author) / Wang, Jinghua (author) / Ji, Saisai (author) / Zhao, Feng (author) / Chang, Xiaochen (author) / Qu, Yingli (author) / Zhu, Yuanduo (author) / Xie, Linna (author)
2023-01-24
Article (Journal)
Electronic Resource
English
Longitudinal trends of per- and polyfluoroalkyl substances in children's serum
| DOAJ | 2018