A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment
https://orcid.org/0000-0002-5303-0452
Abstract Cancer is a key public health concern, being the second leading cause of worldwide morbidity and mortality after cardiovascular diseases. At the global level, cancer prevalence, incidence and mortality rates are increasing. These trends are not fully explained by a growing and ageing population: with marked regional and socioeconomic disparities, lifestyle factors, the resources dedicated to preventive medicine, and the occupational and environmental control of hazardous chemicals all playing a role. While it is difficult to establish the contribution of chemical exposure to the societal burden of cancer, a number of measures can be taken to better assess the carcinogenic properties of chemicals and manage their risks. This paper discusses how these measures can be informed not only by the traditional data streams of regulatory toxicology, but also by using new toxicological assessment methods, along with indicators of public health status based on biomonitoring. These diverse evidence streams have the potential to form the basis of an integrated and more effective approach to cancer prevention.
Graphical abstract Opportunities for carcinogenicity assessment to address the challenges of cancer disease and chemicals in the environment. The safety assessment of carcinogenicity needs to evolve to keep pace with changes in the chemical environment and cancer epidemiology. Future strategies for assessing carcinogenicity based on a more holistic approach, can take into account the prevalence of certain cancers, the contribution to the disease of different risk factors, the study of relationships between chemical exposures and risk factors, the disease aetiology and links with other disorders. In addition, changes in chemical exposure patterns and exposed populations are also critical considerations. Display Omitted
Highlights Cancer has become a key public health concern worldwide and at EU level. Cancer disease is a central priority of EU public health policy. Public health policy actions cannot be decoupled from environmental policy actions. Carcinogenicity assessment must evolve to ensure adequate levels of human protection. The regulatory assessment of chemical toxicity should consider human specific cancers.
Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment
https://orcid.org/0000-0002-5303-0452
Abstract Cancer is a key public health concern, being the second leading cause of worldwide morbidity and mortality after cardiovascular diseases. At the global level, cancer prevalence, incidence and mortality rates are increasing. These trends are not fully explained by a growing and ageing population: with marked regional and socioeconomic disparities, lifestyle factors, the resources dedicated to preventive medicine, and the occupational and environmental control of hazardous chemicals all playing a role. While it is difficult to establish the contribution of chemical exposure to the societal burden of cancer, a number of measures can be taken to better assess the carcinogenic properties of chemicals and manage their risks. This paper discusses how these measures can be informed not only by the traditional data streams of regulatory toxicology, but also by using new toxicological assessment methods, along with indicators of public health status based on biomonitoring. These diverse evidence streams have the potential to form the basis of an integrated and more effective approach to cancer prevention.
Graphical abstract Opportunities for carcinogenicity assessment to address the challenges of cancer disease and chemicals in the environment. The safety assessment of carcinogenicity needs to evolve to keep pace with changes in the chemical environment and cancer epidemiology. Future strategies for assessing carcinogenicity based on a more holistic approach, can take into account the prevalence of certain cancers, the contribution to the disease of different risk factors, the study of relationships between chemical exposures and risk factors, the disease aetiology and links with other disorders. In addition, changes in chemical exposure patterns and exposed populations are also critical considerations. Display Omitted
Highlights Cancer has become a key public health concern worldwide and at EU level. Cancer disease is a central priority of EU public health policy. Public health policy actions cannot be decoupled from environmental policy actions. Carcinogenicity assessment must evolve to ensure adequate levels of human protection. The regulatory assessment of chemical toxicity should consider human specific cancers.
Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment
https://orcid.org/0000-0002-5303-0452
Abstract Cancer is a key public health concern, being the second leading cause of worldwide morbidity and mortality after cardiovascular diseases. At the global level, cancer prevalence, incidence and mortality rates are increasing. These trends are not fully explained by a growing and ageing population: with marked regional and socioeconomic disparities, lifestyle factors, the resources dedicated to preventive medicine, and the occupational and environmental control of hazardous chemicals all playing a role. While it is difficult to establish the contribution of chemical exposure to the societal burden of cancer, a number of measures can be taken to better assess the carcinogenic properties of chemicals and manage their risks. This paper discusses how these measures can be informed not only by the traditional data streams of regulatory toxicology, but also by using new toxicological assessment methods, along with indicators of public health status based on biomonitoring. These diverse evidence streams have the potential to form the basis of an integrated and more effective approach to cancer prevention.
Graphical abstract Opportunities for carcinogenicity assessment to address the challenges of cancer disease and chemicals in the environment. The safety assessment of carcinogenicity needs to evolve to keep pace with changes in the chemical environment and cancer epidemiology. Future strategies for assessing carcinogenicity based on a more holistic approach, can take into account the prevalence of certain cancers, the contribution to the disease of different risk factors, the study of relationships between chemical exposures and risk factors, the disease aetiology and links with other disorders. In addition, changes in chemical exposure patterns and exposed populations are also critical considerations. Display Omitted
Highlights Cancer has become a key public health concern worldwide and at EU level. Cancer disease is a central priority of EU public health policy. Public health policy actions cannot be decoupled from environmental policy actions. Carcinogenicity assessment must evolve to ensure adequate levels of human protection. The regulatory assessment of chemical toxicity should consider human specific cancers.
Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment
Madia, Federica (author) / Worth, Andrew (author) / Whelan, Maurice (author) / Corvi, Raffaella (author)
Environmental International ; 128 ; 417-429
2019-04-27
13 pages
Article (Journal)
Electronic Resource
English
Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment
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