Evaluating the tumorigenic potency of polynuclear aromatic hydrocarbons: Fid-Bau Portal

Evaluating the tumorigenic potency of polynuclear aromatic hydrocarbons

Glass, Larry R. / Easterly, Clay E.

Abstract This research explored some underlying features of a newly developed method that allows for a model-free ranking of the carcinogenic potential of hazardous chemicals. The basis of the ranking technique is the integration of a wide variety of carcinogen bioassays and ultimately the comparison of the potencies of different compounds on a common scale. The value of the approach is that it allows for a ranking of the hazards represented by a list of compound when calibrated to a reference, such as benzo(a)pyrene or other chemical for which exposure guidelines are well developed. The presented research efforts indicate that the ranking of a variety compounds is independent of the reference compound used to standardize the information (p≤0.02 in 14 of the 15 replicates tested). The ranking technique is demonstrated using a variety of polynuclear aromatic hydrocarbons. The method described can be of assistance to industrial hygienists and other health professionals who are required to set exposure limits for the workplace or elsewhere, prior to the substance undergoing extensive agency, committee, or association review.