A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Design of pH-responsive antimicrobial nanocomposite as dual drug delivery system for tumor therapy
https://orcid.org/0000-0001-9284-0055
AbstractA novel antibacterial clay/polymer nanocomposite with average particle size of 20–40nm and two cationic compartments in polymer was synthesized via ion exchange. The structure of the nanocomposites was characterized by XRD, FT-IR, TG-DTA, and SEM. This multifunctional nanocomposite was used for dual drug delivery of anticancer drug methotrexate (MTX) and an antibacterial agent ciprofloxacin (CIP) with encapsulation efficiency of >90% for both drugs. The in vitro antimicrobial activity of the clay/polymer nanocomposites was studied against Escherichia coli and Pseudomonas aeruginosa bacteria by a well diffusion method. The nanocomposite showed good or moderate antimicrobial activities. However, CIP loaded nanocomposites showed enhanced antimicrobial activity in comparison to free CIP. The potential antitumoral activity of this clay/polymer nanocomposite system was evaluated against MCF7 cell lines by MTT assay and cell cycle studies. The cytotoxicity studies demonstrated enhanced cytotoxicity of developed MTX loaded nanocomposite in comparison to free MTX. Cell cycle study showed that MTX-loaded nanocomposite caused S-phased arrest in MCF-7 cells compared to control non-treated cells (P<0.001). Therefore, dual drug-loaded antibacterial nanocomposite has the potential to be used for cancer therapy.
HighlightsNanocomposites prepared with particle size in the range of 20-40 nm.Nanocomposites had potent antibacterial property and pH responsive dual drug loading/release property.The cytotoxicity studies demonstrated enhanced cytotoxicity of MTX loaded nanocomposite with dose dependent manner.Cell cycle study showed that MTX administration caused S-phased arrest in MCF-7 cells compared to control non-treated cells.Our developed novel drug delivery vehicle makes antibacterial and anticancer therapeutic processes proceed spontaneously
Design of pH-responsive antimicrobial nanocomposite as dual drug delivery system for tumor therapy
https://orcid.org/0000-0001-9284-0055
AbstractA novel antibacterial clay/polymer nanocomposite with average particle size of 20–40nm and two cationic compartments in polymer was synthesized via ion exchange. The structure of the nanocomposites was characterized by XRD, FT-IR, TG-DTA, and SEM. This multifunctional nanocomposite was used for dual drug delivery of anticancer drug methotrexate (MTX) and an antibacterial agent ciprofloxacin (CIP) with encapsulation efficiency of >90% for both drugs. The in vitro antimicrobial activity of the clay/polymer nanocomposites was studied against Escherichia coli and Pseudomonas aeruginosa bacteria by a well diffusion method. The nanocomposite showed good or moderate antimicrobial activities. However, CIP loaded nanocomposites showed enhanced antimicrobial activity in comparison to free CIP. The potential antitumoral activity of this clay/polymer nanocomposite system was evaluated against MCF7 cell lines by MTT assay and cell cycle studies. The cytotoxicity studies demonstrated enhanced cytotoxicity of developed MTX loaded nanocomposite in comparison to free MTX. Cell cycle study showed that MTX-loaded nanocomposite caused S-phased arrest in MCF-7 cells compared to control non-treated cells (P<0.001). Therefore, dual drug-loaded antibacterial nanocomposite has the potential to be used for cancer therapy.
HighlightsNanocomposites prepared with particle size in the range of 20-40 nm.Nanocomposites had potent antibacterial property and pH responsive dual drug loading/release property.The cytotoxicity studies demonstrated enhanced cytotoxicity of MTX loaded nanocomposite with dose dependent manner.Cell cycle study showed that MTX administration caused S-phased arrest in MCF-7 cells compared to control non-treated cells.Our developed novel drug delivery vehicle makes antibacterial and anticancer therapeutic processes proceed spontaneously
Design of pH-responsive antimicrobial nanocomposite as dual drug delivery system for tumor therapy
https://orcid.org/0000-0001-9284-0055
AbstractA novel antibacterial clay/polymer nanocomposite with average particle size of 20–40nm and two cationic compartments in polymer was synthesized via ion exchange. The structure of the nanocomposites was characterized by XRD, FT-IR, TG-DTA, and SEM. This multifunctional nanocomposite was used for dual drug delivery of anticancer drug methotrexate (MTX) and an antibacterial agent ciprofloxacin (CIP) with encapsulation efficiency of >90% for both drugs. The in vitro antimicrobial activity of the clay/polymer nanocomposites was studied against Escherichia coli and Pseudomonas aeruginosa bacteria by a well diffusion method. The nanocomposite showed good or moderate antimicrobial activities. However, CIP loaded nanocomposites showed enhanced antimicrobial activity in comparison to free CIP. The potential antitumoral activity of this clay/polymer nanocomposite system was evaluated against MCF7 cell lines by MTT assay and cell cycle studies. The cytotoxicity studies demonstrated enhanced cytotoxicity of developed MTX loaded nanocomposite in comparison to free MTX. Cell cycle study showed that MTX-loaded nanocomposite caused S-phased arrest in MCF-7 cells compared to control non-treated cells (P<0.001). Therefore, dual drug-loaded antibacterial nanocomposite has the potential to be used for cancer therapy.
HighlightsNanocomposites prepared with particle size in the range of 20-40 nm.Nanocomposites had potent antibacterial property and pH responsive dual drug loading/release property.The cytotoxicity studies demonstrated enhanced cytotoxicity of MTX loaded nanocomposite with dose dependent manner.Cell cycle study showed that MTX administration caused S-phased arrest in MCF-7 cells compared to control non-treated cells.Our developed novel drug delivery vehicle makes antibacterial and anticancer therapeutic processes proceed spontaneously
Design of pH-responsive antimicrobial nanocomposite as dual drug delivery system for tumor therapy
Zeynabad, Fatemeh Bazmi (author) / Salehi, Roya (author) / Mahkam, Mehrdad (author)
Applied Clay Science ; 141 ; 23-35
2017-02-12
13 pages
Article (Journal)
Electronic Resource
English
Design of pH-responsive antimicrobial nanocomposite as dual drug delivery system for tumor therapy
| Online Contents | 2017
A novel dual thermo- and pH-responsive silver nanocomposite hydrogel as a drug delivery system
| British Library Online Contents | 2017
| British Library Online Contents | 2004
A dual-targeting drug co-delivery system for tumor chemo- and gene combined therapy
| British Library Online Contents | 2016