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Direct write printing of three-dimensional ZrO2 biological scaffolds
Graphical abstract Three-dimensional (3D) zirconium dioxide (ZrO2) scaffolds have been fabricated for biological engineering by direct write printing method. The water-based ZrO2 ink with a solid content fraction of 70wt% was deposited through a fine nozzle on the substrate by a layer-by-layer sequence to produce the 3D microperiodic structures. Under a microscope, the proliferation of HCT116 cells can be observed around the 3D ZrO2 scaffolds. 3D porous internal architecture is beneficial for cell growth by providing more locations for cell attachment and proliferation. The largest value of compressive strength reached 10MPa, which is more than that of the hydroxyapatite (HAp) scaffold. The ability of printing 3D scaffolds with the high precise control of their internal architecture is the unique characteristics performed by the direct write technique, which will provide potential application of biomaterials and tissue engineering scaffolds. (a) Top view of the sintered 3D woodpile ZrO2 scaffold; (b) top view of the sintered 3D cylindrical ZrO2 scaffold. Display Omitted
Highlights 3D cylindrical and woodpile ZrO2 scaffolds were fabricated by direct write printing method. The compressive strength of the sample with porosity about 63% was 8MPa. The compressive strength of the porosity 55% sample was 10MPa. 3D porous ZrO2 scaffolds with interconnected architecture are beneficial for cell attachment and proliferation.
Abstract Three-dimensional (3D) zirconium dioxide (ZrO2) scaffolds have been fabricated for biological engineering by direct write printing method. The water-based ZrO2 ink with a solid content fraction of 70wt% was deposited through a fine nozzle on the substrate by a layer-by-layer sequence to produce the 3D microperiodic structures. The preparation and the rheological behavior of this ink, as well as the principles of the direct write printing process were investigated systematically. Sintered at 1250°C for 4h was the optimal process for the uniform grain size and a certain amount of pores. No phase change was observed during the sintering process. Under a microscope, the proliferation of HCT116 cells can be observed around the 3D ZrO2 scaffolds. 3D porous internal architecture is beneficial for cell growth by providing more locations for cells attachments and proliferations. The largest value of compressive strength reached 10MPa, which is more than that of the hydroxyapatite (HAp) scaffold. The ability of printing 3D scaffolds with the high precise control of their internal architecture is the unique characteristics performed by the direct write technique, which will provide potential application of biomaterials and tissue engineering scaffolds.
Direct write printing of three-dimensional ZrO2 biological scaffolds
Graphical abstract Three-dimensional (3D) zirconium dioxide (ZrO2) scaffolds have been fabricated for biological engineering by direct write printing method. The water-based ZrO2 ink with a solid content fraction of 70wt% was deposited through a fine nozzle on the substrate by a layer-by-layer sequence to produce the 3D microperiodic structures. Under a microscope, the proliferation of HCT116 cells can be observed around the 3D ZrO2 scaffolds. 3D porous internal architecture is beneficial for cell growth by providing more locations for cell attachment and proliferation. The largest value of compressive strength reached 10MPa, which is more than that of the hydroxyapatite (HAp) scaffold. The ability of printing 3D scaffolds with the high precise control of their internal architecture is the unique characteristics performed by the direct write technique, which will provide potential application of biomaterials and tissue engineering scaffolds. (a) Top view of the sintered 3D woodpile ZrO2 scaffold; (b) top view of the sintered 3D cylindrical ZrO2 scaffold. Display Omitted
Highlights 3D cylindrical and woodpile ZrO2 scaffolds were fabricated by direct write printing method. The compressive strength of the sample with porosity about 63% was 8MPa. The compressive strength of the porosity 55% sample was 10MPa. 3D porous ZrO2 scaffolds with interconnected architecture are beneficial for cell attachment and proliferation.
Abstract Three-dimensional (3D) zirconium dioxide (ZrO2) scaffolds have been fabricated for biological engineering by direct write printing method. The water-based ZrO2 ink with a solid content fraction of 70wt% was deposited through a fine nozzle on the substrate by a layer-by-layer sequence to produce the 3D microperiodic structures. The preparation and the rheological behavior of this ink, as well as the principles of the direct write printing process were investigated systematically. Sintered at 1250°C for 4h was the optimal process for the uniform grain size and a certain amount of pores. No phase change was observed during the sintering process. Under a microscope, the proliferation of HCT116 cells can be observed around the 3D ZrO2 scaffolds. 3D porous internal architecture is beneficial for cell growth by providing more locations for cells attachments and proliferations. The largest value of compressive strength reached 10MPa, which is more than that of the hydroxyapatite (HAp) scaffold. The ability of printing 3D scaffolds with the high precise control of their internal architecture is the unique characteristics performed by the direct write technique, which will provide potential application of biomaterials and tissue engineering scaffolds.
Direct write printing of three-dimensional ZrO2 biological scaffolds
Li, Ya-yun (author) / Li, Long-tu (author) / Li, Bo (author)
2015-02-22
5 pages
Article (Journal)
Electronic Resource
English
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