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Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes
Highlights The link between non-occupational pesticides exposure and 35 biological markers was assessed. Pesticide exposure in months, in years and specific pesticides use associated with TC and LDL. OPE and PEM associated with haematocrit in females; PEU associated with platelets in males. In males, OPE associated with total protein and albumin; OPE and PEM associated with LH. Biological markers seem indicative of adverse effects of pesticides and warrants further study.
Abstract Background Occupational exposure to pesticides has been reported among general population worldwide. However, little is known about the associations between non-occupational exposure to pesticides, and biological markers of health and their response by sex. Objectives We aimed to assess the associations between non-occupational overall pesticide exposure, length of exposure and specific pesticides reported with 35 biological markers of health representing cardiometabolic, haematological, lung function, sex hormones, liver and kidney function profiles, and vitamin D in Finnish cohort. Methods 31-year cross-sectional examination of the Northern Finland Birth Cohort 1966 provided blood samples for biomarker measurements in 1997–1998. Number of subjects varied between 2361 and 5037 for given exposures and certain outcome associations. Multivariable regression analyses were performed to examine associations between overall pesticide exposure (OPE), length of pesticide exposure in months (PEM), in years (PEY), and specific pesticides use (PEU) or not with cardiometabolic [SBP, DBP, TC, LDL, HDL, triglycerides, fasting glucose, insulin, HOMA-IR, HOMA-B, HOMA-S, hs-CRP], hematological [WBC, RBC, Hb, HCT, MCV, MCH, MCHC, platelets], lung function (FVC, FEV1), sex hormones [luteinizing hormone (LH), testosterone (TT), sex-hormone binding globulin (SHBG)], liver and kidney function profiles [total protein, albumin, globulin, ALP, ALT, GGT, urea, creatinine], and vitamin D adjusting for sex, BMI, socioeconomic position (SEP) and season of pesticide use. Results This cohort study on up to 5037 adults with non-occupational OPE, PEM, PEY and PEU differed by sex and SEP. In regression analyses, all the exposures were positively associated with total cholesterol and low-density lipoprotein cholesterol, and PEU was negatively associated with high-density lipoprotein cholesterol in females. OPE and PEM were positively associated with haematocrit in females and PEU with platelets in males. PEU was negatively associated with mean corpuscular haemoglobin. OPE and PEM were positively associated with LH in males. OPE was negatively associated with total protein and albumin in males. Discussion In Finnish young adults, non-occupational overall pesticide exposure, length of exposure and specific pesticides were associated with multiple biological markers of health. The biological markers seem to be indicative of adverse effects of pesticides and warrant for further studies to replicate the findings and determine the underlying mechanisms.
Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes
Highlights The link between non-occupational pesticides exposure and 35 biological markers was assessed. Pesticide exposure in months, in years and specific pesticides use associated with TC and LDL. OPE and PEM associated with haematocrit in females; PEU associated with platelets in males. In males, OPE associated with total protein and albumin; OPE and PEM associated with LH. Biological markers seem indicative of adverse effects of pesticides and warrants further study.
Abstract Background Occupational exposure to pesticides has been reported among general population worldwide. However, little is known about the associations between non-occupational exposure to pesticides, and biological markers of health and their response by sex. Objectives We aimed to assess the associations between non-occupational overall pesticide exposure, length of exposure and specific pesticides reported with 35 biological markers of health representing cardiometabolic, haematological, lung function, sex hormones, liver and kidney function profiles, and vitamin D in Finnish cohort. Methods 31-year cross-sectional examination of the Northern Finland Birth Cohort 1966 provided blood samples for biomarker measurements in 1997–1998. Number of subjects varied between 2361 and 5037 for given exposures and certain outcome associations. Multivariable regression analyses were performed to examine associations between overall pesticide exposure (OPE), length of pesticide exposure in months (PEM), in years (PEY), and specific pesticides use (PEU) or not with cardiometabolic [SBP, DBP, TC, LDL, HDL, triglycerides, fasting glucose, insulin, HOMA-IR, HOMA-B, HOMA-S, hs-CRP], hematological [WBC, RBC, Hb, HCT, MCV, MCH, MCHC, platelets], lung function (FVC, FEV1), sex hormones [luteinizing hormone (LH), testosterone (TT), sex-hormone binding globulin (SHBG)], liver and kidney function profiles [total protein, albumin, globulin, ALP, ALT, GGT, urea, creatinine], and vitamin D adjusting for sex, BMI, socioeconomic position (SEP) and season of pesticide use. Results This cohort study on up to 5037 adults with non-occupational OPE, PEM, PEY and PEU differed by sex and SEP. In regression analyses, all the exposures were positively associated with total cholesterol and low-density lipoprotein cholesterol, and PEU was negatively associated with high-density lipoprotein cholesterol in females. OPE and PEM were positively associated with haematocrit in females and PEU with platelets in males. PEU was negatively associated with mean corpuscular haemoglobin. OPE and PEM were positively associated with LH in males. OPE was negatively associated with total protein and albumin in males. Discussion In Finnish young adults, non-occupational overall pesticide exposure, length of exposure and specific pesticides were associated with multiple biological markers of health. The biological markers seem to be indicative of adverse effects of pesticides and warrant for further studies to replicate the findings and determine the underlying mechanisms.
Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes
Palaniswamy, Saranya (author) / Abass, Khaled (author) / Rysä, Jaana (author) / Odland, Jon Øyvind (author) / Grimalt, Joan O. (author) / Rautio, Arja (author) / Järvelin, Marjo-Riitta (author)
2021-07-06
Article (Journal)
Electronic Resource
English
Pesticides , Non-occupational exposure , Biological markers , Endocrine disrupting chemicals , General population , Finland , ALP , alkaline phosphatase , ALT , alanine aminotransaminase , BMI , body mass index , DBP , diastolic blood pressure , EDCs , endocrine disrupting chemicals , FVC , forced vital capacity , FEV1 , forced expiratory volume in 1 s , GGT , gamma-glutamyl transferase , Hb , haemoglobin , HCT , haematocrit , HDL , high-density lipoprotein cholesterol , HOMA , Homeostatic model assessment , HOMA-IR , HOMA for insulin resistance , HOMA-β , HOMA for assessing β-cell function , HOMA-S , HOMA for insulin sensitivity , hs-CRP , high-sensitivity C-reactive protein , LDL , low-density lipoprotein cholesterol , LH , luteinizing hormone , MCH , mean corpuscular haemoglobin , MCHC , MCH concentration , MCV , mean corpuscular volume , NFBC1966 , Northern Finland Birth Cohort 1966 , OPE , overall pesticide exposure , PEM , pesticide exposure in months , PEU , specific pesticides , PEY , pesticide exposure in years , RBC , total red blood cell , SBP , systolic blood pressure , SHBG , sex-hormone binding globulin , SEP , socioeconomic position , TC , total cholesterol , TG , triglycerides , TT , testosterone , WC , waist circumference , WBC , total leukocyte count.
Online Contents | 2003