A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project
Abstract Organophosphates and carbamates have been among the most commonly used insecticides, with both agricultural and residential uses. Previous studies have suggested associations of non-Hodgkin lymphoma (NHL) with some of these chemicals; however, many studies have been limited in their ability to evaluate associations with lymphoma subtypes. We evaluated the use of eleven organophosphate and two carbamate insecticides in association with NHL in the North American Pooled Project, which includes data from case-control studies in the United States and Canada (1690 cases/5131 controls). We used unconditional logistic regression adjusting for potential confounders, including use of other pesticides, to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations between these chemicals and NHL overall, and NHL subtypes, i.e., follicular (FL), diffuse large B-cell (DLBCL), small lymphocytic lymphoma (SLL) and others. Ever use of malathion was associated with increased risk of NHL overall (OR = 1.43; 95% CI: 1.14–1.81) compared with never users. Categories using tertiles of duration (<4 yrs., 4–12 yrs., and >12 yrs) also showed a significant exposure-response for increasing years of use of malathion and risk of NHL (OR<4vsUnex = 1.33 (0.88, 2.03), OR4-12vsUnex = 1.42 (1.02, 1.96), OR>12vsUnex = 1.55 (1.05, 2.28, p-trend < 0.01)). In addition, malathion use was statistically significantly associated with FL (OR = 1.58; 95% CI: 1.11–2.27) and DLBCL (OR = 1.61; 95% CI: 1.16–2.22) while there were no apparent associations with SLL or other subtypes, the p-value for heterogeneity across subtypes, however, was not significant. These results support previous studies suggesting an association between insecticide use and NHL overall, and provide new information on associations with NHL subtypes.
Highlights Increasing duration of exposure to organophosphate (OP) and carbamate insecticides significantly increases the risk of NHL Increasing years of use of malathion, an OP insecticide, increased the risk of NHL overall Malathion use was also significantly associated with the follicular and diffuse large b-cell subtypes of lymphoma
Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project
Abstract Organophosphates and carbamates have been among the most commonly used insecticides, with both agricultural and residential uses. Previous studies have suggested associations of non-Hodgkin lymphoma (NHL) with some of these chemicals; however, many studies have been limited in their ability to evaluate associations with lymphoma subtypes. We evaluated the use of eleven organophosphate and two carbamate insecticides in association with NHL in the North American Pooled Project, which includes data from case-control studies in the United States and Canada (1690 cases/5131 controls). We used unconditional logistic regression adjusting for potential confounders, including use of other pesticides, to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations between these chemicals and NHL overall, and NHL subtypes, i.e., follicular (FL), diffuse large B-cell (DLBCL), small lymphocytic lymphoma (SLL) and others. Ever use of malathion was associated with increased risk of NHL overall (OR = 1.43; 95% CI: 1.14–1.81) compared with never users. Categories using tertiles of duration (<4 yrs., 4–12 yrs., and >12 yrs) also showed a significant exposure-response for increasing years of use of malathion and risk of NHL (OR<4vsUnex = 1.33 (0.88, 2.03), OR4-12vsUnex = 1.42 (1.02, 1.96), OR>12vsUnex = 1.55 (1.05, 2.28, p-trend < 0.01)). In addition, malathion use was statistically significantly associated with FL (OR = 1.58; 95% CI: 1.11–2.27) and DLBCL (OR = 1.61; 95% CI: 1.16–2.22) while there were no apparent associations with SLL or other subtypes, the p-value for heterogeneity across subtypes, however, was not significant. These results support previous studies suggesting an association between insecticide use and NHL overall, and provide new information on associations with NHL subtypes.
Highlights Increasing duration of exposure to organophosphate (OP) and carbamate insecticides significantly increases the risk of NHL Increasing years of use of malathion, an OP insecticide, increased the risk of NHL overall Malathion use was also significantly associated with the follicular and diffuse large b-cell subtypes of lymphoma
Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project
Koutros, Stella (author) / Harris, Shelley A. (author) / Spinelli, John J. (author) / Blair, Aaron (author) / McLaughlin, John R. (author) / Zahm, Shelia Hoar (author) / Kim, Sungduk (author) / Albert, Paul S. (author) / Kachuri, Linda (author) / Pahwa, Manisha (author)
Environmental International ; 127 ; 199-205
2019-03-08
7 pages
Article (Journal)
Electronic Resource
English
Structural and ultrastructural study of the rabbit testes exposed to carbamate insecticide
| Taylor & Francis Verlag | 2012
Structural and ultrastructural study of the rabbit testes exposed to carbamate insecticide
| Online Contents | 2012