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Does mask wearing affect skin health? An untargeted skin metabolomics study
https://orcid.org/0000-0003-3798-5635
https://orcid.org/0000-0002-8193-9954
Graphical abstract Display Omitted
Highlights D-squame was more suitable for the collection of skin metabolites than sterile gauze. This is the first study to analyze the potential health risks of face masks to the skin at the omics level. The downregulation of skin metabolites caused by the internal environment of N95 respirators was more obvious. Glycerophospholipid metabolism pathway and sphingolipid metabolism pathway were mainly disturbed. Skin metabolism could remain normal if intermittent removal of the surgical masks.
Abstract Wearing masks is used as an effective way to prevent the spread of viruses. However, the effect of wearing masks on skin health requires further assessment. In this study, a non-invasive D-squame sampling method coupled with an untargeted metabolomics analysis by liquid chromatography high-resolution mass spectrometry was developed to identify the changes in the skin metabolome caused by wearing masks. D-squame method was found to have advantages over the commonly used sterile gauze method, especially for the lipids and lipid-like molecules. A total of 356 skin metabolites were putatively identified from the stratum corneum of 10 volunteers, and 17 differential metabolites were significantly downregulated after wearing surgical masks or N95 respirators. The downregulation of metabolites such as phosphatidylethanolamine and sphingomyelin might be related to hypoxia or increased skin moisture caused by wearing masks. Changes in skin metabolomics indicated a potential risk of skin barrier disruption and skin inflammation. Intermittent removal of the masks can effectively alleviate changes in the skin metabolome.
Does mask wearing affect skin health? An untargeted skin metabolomics study
https://orcid.org/0000-0003-3798-5635
https://orcid.org/0000-0002-8193-9954
Graphical abstract Display Omitted
Highlights D-squame was more suitable for the collection of skin metabolites than sterile gauze. This is the first study to analyze the potential health risks of face masks to the skin at the omics level. The downregulation of skin metabolites caused by the internal environment of N95 respirators was more obvious. Glycerophospholipid metabolism pathway and sphingolipid metabolism pathway were mainly disturbed. Skin metabolism could remain normal if intermittent removal of the surgical masks.
Abstract Wearing masks is used as an effective way to prevent the spread of viruses. However, the effect of wearing masks on skin health requires further assessment. In this study, a non-invasive D-squame sampling method coupled with an untargeted metabolomics analysis by liquid chromatography high-resolution mass spectrometry was developed to identify the changes in the skin metabolome caused by wearing masks. D-squame method was found to have advantages over the commonly used sterile gauze method, especially for the lipids and lipid-like molecules. A total of 356 skin metabolites were putatively identified from the stratum corneum of 10 volunteers, and 17 differential metabolites were significantly downregulated after wearing surgical masks or N95 respirators. The downregulation of metabolites such as phosphatidylethanolamine and sphingomyelin might be related to hypoxia or increased skin moisture caused by wearing masks. Changes in skin metabolomics indicated a potential risk of skin barrier disruption and skin inflammation. Intermittent removal of the masks can effectively alleviate changes in the skin metabolome.
Does mask wearing affect skin health? An untargeted skin metabolomics study
https://orcid.org/0000-0003-3798-5635
https://orcid.org/0000-0002-8193-9954
Graphical abstract Display Omitted
Highlights D-squame was more suitable for the collection of skin metabolites than sterile gauze. This is the first study to analyze the potential health risks of face masks to the skin at the omics level. The downregulation of skin metabolites caused by the internal environment of N95 respirators was more obvious. Glycerophospholipid metabolism pathway and sphingolipid metabolism pathway were mainly disturbed. Skin metabolism could remain normal if intermittent removal of the surgical masks.
Abstract Wearing masks is used as an effective way to prevent the spread of viruses. However, the effect of wearing masks on skin health requires further assessment. In this study, a non-invasive D-squame sampling method coupled with an untargeted metabolomics analysis by liquid chromatography high-resolution mass spectrometry was developed to identify the changes in the skin metabolome caused by wearing masks. D-squame method was found to have advantages over the commonly used sterile gauze method, especially for the lipids and lipid-like molecules. A total of 356 skin metabolites were putatively identified from the stratum corneum of 10 volunteers, and 17 differential metabolites were significantly downregulated after wearing surgical masks or N95 respirators. The downregulation of metabolites such as phosphatidylethanolamine and sphingomyelin might be related to hypoxia or increased skin moisture caused by wearing masks. Changes in skin metabolomics indicated a potential risk of skin barrier disruption and skin inflammation. Intermittent removal of the masks can effectively alleviate changes in the skin metabolome.
Does mask wearing affect skin health? An untargeted skin metabolomics study
Liu, Yu (author) / Zhao, Hongzhi (author) / Chen, Hao (author) / Li, Xinxin (author) / Ran, Chunmei (author) / Sun, Hongwen (author) / Wang, Lei (author)
2023-06-28
Article (Journal)
Electronic Resource
English
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